Stereoselective synthesis of individual isomers of Leu-enkephalin analogues containing substituted β-turn bicyclic dipeptide mimetics

Chiyi Xiong; Junyi Zhang; Peg Davis; Wei Wang; Jinfa Ying; Frank Porreca; Victor J. Hruby

doi:10.1039/b302235h

Stereoselective synthesis of individual isomers of Leu-enkephalin analogues containing substituted β-turn bicyclic dipeptide mimetics

Chiyi Xiong, Junyi Zhang, Peg Davis, Wei Wang, Jinfa Ying, Frank Porreca, Victor J. Hruby

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Novel constrained β-turn dipeptide mimetics, 8-phenyl thiaindolizidinone amino acids 3, have been synthesized stereoselectively and incorporated into Leu-enkephalin peptides as a replacement of dipeptide Gly3-Phe4 to afford four individual isomers of Leu-enkephalin analogues 6.

Original language	English (US)
Pages (from-to)	1598-1599
Number of pages	2
Journal	Chemical Communications
Volume	3
Issue number	13
DOIs	https://doi.org/10.1039/b302235h
State	Published - 2003

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Stereoselective synthesis of individual isomers of Leu-enkephalin analogues containing substituted β-turn bicyclic dipeptide mimetics",

abstract = "Novel constrained β-turn dipeptide mimetics, 8-phenyl thiaindolizidinone amino acids 3, have been synthesized stereoselectively and incorporated into Leu-enkephalin peptides as a replacement of dipeptide Gly3-Phe4 to afford four individual isomers of Leu-enkephalin analogues 6.",

author = "Chiyi Xiong and Junyi Zhang and Peg Davis and Wei Wang and Jinfa Ying and Frank Porreca and Hruby, {Victor J.}",

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T1 - Stereoselective synthesis of individual isomers of Leu-enkephalin analogues containing substituted β-turn bicyclic dipeptide mimetics

AU - Xiong, Chiyi

AU - Zhang, Junyi

AU - Davis, Peg

AU - Wang, Wei

AU - Ying, Jinfa

AU - Porreca, Frank

AU - Hruby, Victor J.

PY - 2003

Y1 - 2003

N2 - Novel constrained β-turn dipeptide mimetics, 8-phenyl thiaindolizidinone amino acids 3, have been synthesized stereoselectively and incorporated into Leu-enkephalin peptides as a replacement of dipeptide Gly3-Phe4 to afford four individual isomers of Leu-enkephalin analogues 6.

AB - Novel constrained β-turn dipeptide mimetics, 8-phenyl thiaindolizidinone amino acids 3, have been synthesized stereoselectively and incorporated into Leu-enkephalin peptides as a replacement of dipeptide Gly3-Phe4 to afford four individual isomers of Leu-enkephalin analogues 6.

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DO - 10.1039/b302235h

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ER -

Stereoselective synthesis of individual isomers of Leu-enkephalin analogues containing substituted β-turn bicyclic dipeptide mimetics

Abstract

ASJC Scopus subject areas

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