Abstract
Preclinical studies suggest that mesenchymal stem cells (MSCs) may represent a potential therapeutic option for the treatment of chronic lung diseases including Idiopathic Pulmonary Fibrosis (IPF). IPF is an inexorably progressive lung disease of unknown origin. Despite the recent availability of two approved treatment options, median survival remains poor at 3–5 years. While there remains a pressing need for further exploration of interval endpoints and biomarkers, promising results of Phase 1 studies of MSCs have reduced safety concerns and encouraged further interest in the potential applicability of cell-based therapeutic approaches for chronic lung diseases like IPF. This chapter will summarize the current state of knowledge regarding the use of stem cells for the treatment of IPF, present important safety and efficacy issues highlighting current and future challenges, and address the need for large, multicenter clinical trials coupled with realistic end-points, including biomarkers, to assess treatment efficacy.
Original language | English (US) |
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Title of host publication | Stem Cell-Based Therapy for Lung Disease |
Publisher | Springer International Publishing |
Pages | 119-130 |
Number of pages | 12 |
ISBN (Electronic) | 9783030294038 |
ISBN (Print) | 9783030294021 |
DOIs | |
State | Published - Jan 1 2019 |
Externally published | Yes |
Keywords
- Efficacy
- Idiopathic pulmonary fibrosis
- Mesenchymal stem cells
- Safety
- Treatment
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
- General Medicine