Stearidonic and γ-linolenic acids in echium oil improves glucose disposal in insulin resistant monkeys

K. Kavanagh, D. M. Flynn, K. A. Jenkins, M. D. Wilson, F. H. Chilton

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Echium oil (EO) contains stearidonic acid (18:4), a n-3 polyunsaturated fatty acids (PUFAs), and gamma-linolenic acids (18:3), a n-6 PUFA that can be converted to long chain (LC)-PUFAs. We aimed to compare a safflower oil (SO)-enriched diet to EO- and fish oil (FO)-enriched diets on circulating and tissue PUFAs levels and glycemic, inflammatory, and cardiovascular health biomarkers in insulin resistant African green monkeys. In a Latin-square cross-over study, eight monkeys consumed matched diets for 6 weeks with 3-week washout periods. Monkeys consuming FO had significantly higher levels of n-3 LC-PUFAs and EO supplementation resulted in higher levels of circulating n-3 LC-PUFAs and a significant increase in dihomo-gamma linolenic acid (DGLA) in red blood cells and muscle. Glucose disposal was improved after EO consumption. These data suggest that PUFAs in EO supplementation have the capacity to alter circulating, RBC and muscle LC-PUFA levels and improve glucose tolerance in insulin-resistant monkeys.

Original languageEnglish (US)
Pages (from-to)39-45
Number of pages7
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Issue number1
StatePublished - Jul 2013
Externally publishedYes


  • Diabetes
  • Echium oil
  • Fish oil
  • Gamma-Linolenic acid
  • Polyunsaturated fatty acids
  • Stearidonic acid

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology


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