Stearidonic and γ-linolenic acids in echium oil improves glucose disposal in insulin resistant monkeys

K. Kavanagh; D. M. Flynn; K. A. Jenkins; M. D. Wilson; F. H. Chilton

doi:10.1016/j.plefa.2013.04.003

Stearidonic and γ-linolenic acids in echium oil improves glucose disposal in insulin resistant monkeys

K. Kavanagh, D. M. Flynn, K. A. Jenkins, M. D. Wilson, F. H. Chilton

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Echium oil (EO) contains stearidonic acid (18:4), a n-3 polyunsaturated fatty acids (PUFAs), and gamma-linolenic acids (18:3), a n-6 PUFA that can be converted to long chain (LC)-PUFAs. We aimed to compare a safflower oil (SO)-enriched diet to EO- and fish oil (FO)-enriched diets on circulating and tissue PUFAs levels and glycemic, inflammatory, and cardiovascular health biomarkers in insulin resistant African green monkeys. In a Latin-square cross-over study, eight monkeys consumed matched diets for 6 weeks with 3-week washout periods. Monkeys consuming FO had significantly higher levels of n-3 LC-PUFAs and EO supplementation resulted in higher levels of circulating n-3 LC-PUFAs and a significant increase in dihomo-gamma linolenic acid (DGLA) in red blood cells and muscle. Glucose disposal was improved after EO consumption. These data suggest that PUFAs in EO supplementation have the capacity to alter circulating, RBC and muscle LC-PUFA levels and improve glucose tolerance in insulin-resistant monkeys.

Original language	English (US)
Pages (from-to)	39-45
Number of pages	7
Journal	Prostaglandins Leukotrienes and Essential Fatty Acids
Volume	89
Issue number	1
DOIs	https://doi.org/10.1016/j.plefa.2013.04.003
State	Published - Jul 2013
Externally published	Yes

Keywords

Diabetes
Echium oil
Fish oil
Gamma-Linolenic acid
Polyunsaturated fatty acids
Stearidonic acid

ASJC Scopus subject areas

Clinical Biochemistry
Cell Biology

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10.1016/j.plefa.2013.04.003

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title = "Stearidonic and γ-linolenic acids in echium oil improves glucose disposal in insulin resistant monkeys",

abstract = "Echium oil (EO) contains stearidonic acid (18:4), a n-3 polyunsaturated fatty acids (PUFAs), and gamma-linolenic acids (18:3), a n-6 PUFA that can be converted to long chain (LC)-PUFAs. We aimed to compare a safflower oil (SO)-enriched diet to EO- and fish oil (FO)-enriched diets on circulating and tissue PUFAs levels and glycemic, inflammatory, and cardiovascular health biomarkers in insulin resistant African green monkeys. In a Latin-square cross-over study, eight monkeys consumed matched diets for 6 weeks with 3-week washout periods. Monkeys consuming FO had significantly higher levels of n-3 LC-PUFAs and EO supplementation resulted in higher levels of circulating n-3 LC-PUFAs and a significant increase in dihomo-gamma linolenic acid (DGLA) in red blood cells and muscle. Glucose disposal was improved after EO consumption. These data suggest that PUFAs in EO supplementation have the capacity to alter circulating, RBC and muscle LC-PUFA levels and improve glucose tolerance in insulin-resistant monkeys.",

keywords = "Diabetes, Echium oil, Fish oil, Gamma-Linolenic acid, Polyunsaturated fatty acids, Stearidonic acid",

author = "K. Kavanagh and Flynn, {D. M.} and Jenkins, {K. A.} and Wilson, {M. D.} and Chilton, {F. H.}",

note = "Funding Information: Funding for these studies came from grants P50 AT002782 , K01AG 033641 , and T32HL07115 as well as Wake Forest School of Medicine . No conflicts of interest are present for any of the authors. The authors gratefully acknowledge the advice and input from Drs. Lawrence L. Rudel and John S. Parks.",

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AU - Kavanagh, K.

AU - Flynn, D. M.

AU - Jenkins, K. A.

AU - Wilson, M. D.

AU - Chilton, F. H.

N1 - Funding Information: Funding for these studies came from grants P50 AT002782 , K01AG 033641 , and T32HL07115 as well as Wake Forest School of Medicine . No conflicts of interest are present for any of the authors. The authors gratefully acknowledge the advice and input from Drs. Lawrence L. Rudel and John S. Parks.

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KW - Polyunsaturated fatty acids

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Stearidonic and γ-linolenic acids in echium oil improves glucose disposal in insulin resistant monkeys

Abstract

Keywords

ASJC Scopus subject areas

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