Standard of care for lipedema in the United States

Karen L. Herbst; Linda Anne Kahn; Emily Iker; Chuck Ehrlich; Thomas Wright; Lindy McHutchison; Jaime Schwartz; Molly Sleigh; Paula M.C. Donahue; Kathleen H. Lisson; Tami Faris; Janis Miller; Erik Lontok; Michael S. Schwartz; Steven M. Dean; John R. Bartholomew; Polly Armour; Margarita Correa-Perez; Nicholas Pennings; Edely L. Wallace; Ethan Larson

doi:10.1177/02683555211015887

Standard of care for lipedema in the United States

Karen L. Herbst, Linda Anne Kahn, Emily Iker, Chuck Ehrlich, Thomas Wright, Lindy McHutchison, Jaime Schwartz, Molly Sleigh, Paula M.C. Donahue, Kathleen H. Lisson, Tami Faris, Janis Miller, Erik Lontok, Michael S. Schwartz, Steven M. Dean, John R. Bartholomew, Polly Armour, Margarita Correa-Perez, Nicholas Pennings, Edely L. WallaceEthan Larson

Surgery

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

Background: Lipedema is a loose connective tissue disease predominantly in women identified by increased nodular and fibrotic adipose tissue on the buttocks, hips and limbs that develops at times of hormone, weight and shape change including puberty, pregnancy, and menopause. Lipedema tissue may be very painful and can severely impair mobility. Non-lipedema obesity, lymphedema, venous disease, and hypermobile joints are comorbidities. Lipedema tissue is difficult to reduce by diet, exercise, or bariatric surgery. Methods: This paper is a consensus guideline on lipedema written by a US committee following the Delphi Method. Consensus statements are rated for strength using the GRADE system. Results: Eighty-five consensus statements outline lipedema pathophysiology, and medical, surgical, vascular, and other therapeutic recommendations. Future research topics are suggested. Conclusion: These guidelines improve the understanding of the loose connective tissue disease, lipedema, to advance our understanding towards early diagnosis, treatments, and ultimately a cure for affected individuals.

Original language	English (US)
Pages (from-to)	779-796
Number of pages	18
Journal	Phlebology
Volume	36
Issue number	10
DOIs	https://doi.org/10.1177/02683555211015887
State	Published - Dec 2021

Keywords

Lipedema
chronic venous disease
hypermobility
lymphedema
standard of care

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1177/02683555211015887

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Herbst, K. L., Kahn, L. A., Iker, E., Ehrlich, C., Wright, T., McHutchison, L., Schwartz, J., Sleigh, M., Donahue, P. M. C., Lisson, K. H., Faris, T., Miller, J., Lontok, E., Schwartz, M. S., Dean, S. M., Bartholomew, J. R., Armour, P., Correa-Perez, M., Pennings, N., ... Larson, E. (2021). Standard of care for lipedema in the United States. Phlebology, 36(10), 779-796. https://doi.org/10.1177/02683555211015887

Herbst, KL, Kahn, LA, Iker, E, Ehrlich, C, Wright, T, McHutchison, L, Schwartz, J, Sleigh, M, Donahue, PMC, Lisson, KH, Faris, T, Miller, J, Lontok, E, Schwartz, MS, Dean, SM, Bartholomew, JR, Armour, P, Correa-Perez, M, Pennings, N, Wallace, EL & Larson, E 2021, 'Standard of care for lipedema in the United States', Phlebology, vol. 36, no. 10, pp. 779-796. https://doi.org/10.1177/02683555211015887

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abstract = "Background: Lipedema is a loose connective tissue disease predominantly in women identified by increased nodular and fibrotic adipose tissue on the buttocks, hips and limbs that develops at times of hormone, weight and shape change including puberty, pregnancy, and menopause. Lipedema tissue may be very painful and can severely impair mobility. Non-lipedema obesity, lymphedema, venous disease, and hypermobile joints are comorbidities. Lipedema tissue is difficult to reduce by diet, exercise, or bariatric surgery. Methods: This paper is a consensus guideline on lipedema written by a US committee following the Delphi Method. Consensus statements are rated for strength using the GRADE system. Results: Eighty-five consensus statements outline lipedema pathophysiology, and medical, surgical, vascular, and other therapeutic recommendations. Future research topics are suggested. Conclusion: These guidelines improve the understanding of the loose connective tissue disease, lipedema, to advance our understanding towards early diagnosis, treatments, and ultimately a cure for affected individuals.",

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author = "Herbst, {Karen L.} and Kahn, {Linda Anne} and Emily Iker and Chuck Ehrlich and Thomas Wright and Lindy McHutchison and Jaime Schwartz and Molly Sleigh and Donahue, {Paula M.C.} and Lisson, {Kathleen H.} and Tami Faris and Janis Miller and Erik Lontok and Schwartz, {Michael S.} and Dean, {Steven M.} and Bartholomew, {John R.} and Polly Armour and Margarita Correa-Perez and Nicholas Pennings and Wallace, {Edely L.} and Ethan Larson",

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year = "2021",

month = dec,

doi = "10.1177/02683555211015887",

language = "English (US)",

volume = "36",

pages = "779--796",

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AU - Herbst, Karen L.

AU - Kahn, Linda Anne

AU - Iker, Emily

AU - Ehrlich, Chuck

AU - Wright, Thomas

AU - McHutchison, Lindy

AU - Schwartz, Jaime

AU - Sleigh, Molly

AU - Donahue, Paula M.C.

AU - Lisson, Kathleen H.

AU - Faris, Tami

AU - Miller, Janis

AU - Lontok, Erik

AU - Schwartz, Michael S.

AU - Dean, Steven M.

AU - Bartholomew, John R.

AU - Armour, Polly

AU - Correa-Perez, Margarita

AU - Pennings, Nicholas

AU - Wallace, Edely L.

AU - Larson, Ethan

PY - 2021/12

Y1 - 2021/12

N2 - Background: Lipedema is a loose connective tissue disease predominantly in women identified by increased nodular and fibrotic adipose tissue on the buttocks, hips and limbs that develops at times of hormone, weight and shape change including puberty, pregnancy, and menopause. Lipedema tissue may be very painful and can severely impair mobility. Non-lipedema obesity, lymphedema, venous disease, and hypermobile joints are comorbidities. Lipedema tissue is difficult to reduce by diet, exercise, or bariatric surgery. Methods: This paper is a consensus guideline on lipedema written by a US committee following the Delphi Method. Consensus statements are rated for strength using the GRADE system. Results: Eighty-five consensus statements outline lipedema pathophysiology, and medical, surgical, vascular, and other therapeutic recommendations. Future research topics are suggested. Conclusion: These guidelines improve the understanding of the loose connective tissue disease, lipedema, to advance our understanding towards early diagnosis, treatments, and ultimately a cure for affected individuals.

AB - Background: Lipedema is a loose connective tissue disease predominantly in women identified by increased nodular and fibrotic adipose tissue on the buttocks, hips and limbs that develops at times of hormone, weight and shape change including puberty, pregnancy, and menopause. Lipedema tissue may be very painful and can severely impair mobility. Non-lipedema obesity, lymphedema, venous disease, and hypermobile joints are comorbidities. Lipedema tissue is difficult to reduce by diet, exercise, or bariatric surgery. Methods: This paper is a consensus guideline on lipedema written by a US committee following the Delphi Method. Consensus statements are rated for strength using the GRADE system. Results: Eighty-five consensus statements outline lipedema pathophysiology, and medical, surgical, vascular, and other therapeutic recommendations. Future research topics are suggested. Conclusion: These guidelines improve the understanding of the loose connective tissue disease, lipedema, to advance our understanding towards early diagnosis, treatments, and ultimately a cure for affected individuals.

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KW - standard of care

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Standard of care for lipedema in the United States

Abstract

Keywords

ASJC Scopus subject areas

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