Stabilized porous phospholipid nanoshells

Zhiliang Cheng; Gemma D. D'Ambruoso; Craig A. Aspinwall

doi:10.1021/la061542i

Stabilized porous phospholipid nanoshells

Zhiliang Cheng, Gemma D. D'Ambruoso, Craig A. Aspinwall

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Chemically stabilized, porous phospholipid nanoshells (PPNs) were prepared via copolymerization of reactive monomers with unilamellar bis-Sorbyl phosphatidylcholine vesicles. The resulting PPN vesicular assemblies possess a highly porous membrane structure that allows passage of small molecules, which can react with encapsulated proteins and reporters. The unique combination of membrane stability and porosity will prove useful for preparing nanometersized sensor, container, and reactor platforms stable in harsh chemical and biological environments.

Original language	English (US)
Pages (from-to)	9507-9511
Number of pages	5
Journal	Langmuir
Volume	22
Issue number	23
DOIs	https://doi.org/10.1021/la061542i
State	Published - Nov 7 2006

ASJC Scopus subject areas

Materials Science(all)
Condensed Matter Physics
Surfaces and Interfaces
Spectroscopy
Electrochemistry

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10.1021/la061542i

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author = "Zhiliang Cheng and D'Ambruoso, {Gemma D.} and Aspinwall, {Craig A.}",

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AU - Cheng, Zhiliang

AU - D'Ambruoso, Gemma D.

AU - Aspinwall, Craig A.

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AB - Chemically stabilized, porous phospholipid nanoshells (PPNs) were prepared via copolymerization of reactive monomers with unilamellar bis-Sorbyl phosphatidylcholine vesicles. The resulting PPN vesicular assemblies possess a highly porous membrane structure that allows passage of small molecules, which can react with encapsulated proteins and reporters. The unique combination of membrane stability and porosity will prove useful for preparing nanometersized sensor, container, and reactor platforms stable in harsh chemical and biological environments.

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Stabilized porous phospholipid nanoshells

Abstract

ASJC Scopus subject areas

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