Stabilized porous liposomes with encapsulated Gd-labeled dextran as a highly efficient MRI contrast agent

Zhiliang Cheng; Ajlan Al Zaki; Ian W. Jones; Henry K. Hall; Craig A. Aspinwall; Andrew Tsourkas

doi:10.1039/c3cc48939f

Stabilized porous liposomes with encapsulated Gd-labeled dextran as a highly efficient MRI contrast agent

Zhiliang Cheng
, Ajlan Al Zaki
, Ian W. Jones
, Henry K. Hall
, Craig A. Aspinwall
, Andrew Tsourkas

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

A highly efficient contrast agent for magnetic resonance imaging was developed by encapsulating gadolinium within a stabilized porous liposome. The highly porous membrane leads to a high relaxivity of the encapsulated Gd. The stability of the liposome was improved by forming a polymer network within the bilayer membrane.

Original language	English (US)
Pages (from-to)	2502-2504
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	19
DOIs	https://doi.org/10.1039/c3cc48939f
State	Published - Feb 7 2014

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c3cc48939f

Cite this

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title = "Stabilized porous liposomes with encapsulated Gd-labeled dextran as a highly efficient MRI contrast agent",

abstract = "A highly efficient contrast agent for magnetic resonance imaging was developed by encapsulating gadolinium within a stabilized porous liposome. The highly porous membrane leads to a high relaxivity of the encapsulated Gd. The stability of the liposome was improved by forming a polymer network within the bilayer membrane.",

author = "Zhiliang Cheng and \{Al Zaki\}, Ajlan and Jones, \{Ian W.\} and Hall, \{Henry K.\} and Aspinwall, \{Craig A.\} and Andrew Tsourkas",

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AU - Cheng, Zhiliang

AU - Al Zaki, Ajlan

AU - Jones, Ian W.

AU - Hall, Henry K.

AU - Aspinwall, Craig A.

AU - Tsourkas, Andrew

PY - 2014/2/7

Y1 - 2014/2/7

N2 - A highly efficient contrast agent for magnetic resonance imaging was developed by encapsulating gadolinium within a stabilized porous liposome. The highly porous membrane leads to a high relaxivity of the encapsulated Gd. The stability of the liposome was improved by forming a polymer network within the bilayer membrane.

AB - A highly efficient contrast agent for magnetic resonance imaging was developed by encapsulating gadolinium within a stabilized porous liposome. The highly porous membrane leads to a high relaxivity of the encapsulated Gd. The stability of the liposome was improved by forming a polymer network within the bilayer membrane.

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UR - https://www.scopus.com/pages/publications/84893829478#tab=citedBy

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EP - 2504

JO - Chemical Communications

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Stabilized porous liposomes with encapsulated Gd-labeled dextran as a highly efficient MRI contrast agent

Abstract

ASJC Scopus subject areas

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