(S,S)-4′′-Cyano-7,7′′-dimeth-oxy-3′, 6′-dioxodispiro-[indane-2,2′-piperazine-5′, 2′′-indane]-4-carboxamide methanol solvate: Inter-rupting the amide-to-amide hydrogen-bonded tape

The title methanol solvate, C24H22N4O5·CH3OH, forms an extended three-dimensional hydrogen-bonded structure, assisted by the presence of several good donor and acceptor sites. It shows none of the crystal packing features typically expected of piperazinediones, such as amide-to-amide R 2 ²(8) hydrogen bonding. In this structure the methanol solvent appears to play only a space-filling role; it is not involved in any hydrogen bonding and instead is disordered over several sites. This study reports, to the best of our knowledge, the first crystal structure of an indane-containing piperazinedione compound which exhibits a three-dimensional hydrogen-bonded structure formed by classical (N - H⋯O and N - H⋯N) hydrogen-bonding inter-actions.