Spore-forming Bacilli and Clostridia in human disease

Michael Mallozzi, V. K. Viswanathan, Gayatri Vedantam

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations


Many Gram-positive spore-forming bacteria in the Firmicute phylum are important members of the human commensal microbiota, which, in rare cases, cause opportunistic infections. Other spore-formers, however, have evolved to become dedicated pathogens that can cause a striking variety of diseases. Despite variations in disease presentation, the etiologic agent is often the spore, with bacterially produced toxins playing a central role in the pathophysiology of infection. This review will focus on the specific diseases caused by spores of the Clostridia and Bacilli.

Original languageEnglish (US)
Pages (from-to)1109-1123
Number of pages15
JournalFuture Microbiology
Issue number7
StatePublished - Jul 2010


  • Bacillus anthracis
  • Clostridium botulinum
  • Clostridium difficile
  • Clostridium perfringens
  • Clostridium tetani
  • anthrax
  • botulism
  • gas gangrene
  • spore

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)


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