Splenic artery ligation in experimental hypersplenism

The effects of splenic artery ligation (SAL) were examined in Sprague Dawley rats with methyl cellulose induced hypersplenism. When performed close to the splenic hilum, SAL effectively reduced functioning splenic mass and raised peripheral counts of leukocytes and platelets, a response similar to that following total splenectomy. In hypersplenism, therefore, a satisfactory hematologic response may not necessarily require total ablation of the spleen but merely substantial reduction of functioning splenic tissue.