Spinning-disk laser interferometers for immuno-assays and proteomics: The BioCD

D. D. Nolte, M. Varma, L. Peng, D. Inierowicz, F. Regnier

Research output: Contribution to journalConference articlepeer-review

2 Scopus citations


Spinning-disk self-referencing laser interferometers are being developed as high-speed high-sensitivity platforms for immunoassay and proteomics applications. Their compact disc (CD) formats have the potential for ultra-high-throughput multianalyte assays as well as for binding kinetics and quantitative analysis. Self-referencing interferometers are immune to mechanical variations, enabling interferometric sensitivities and speeds that are several orders of magnitude larger than for their counterpart fluorometric techniques. This paper defines for the first time three classes of the BioCD that differ in their method of self-referencing and reviews their relative merits and sensitivities. Each uses a near-field probe with far-field detection. The three classes are: microdiffraction, adaptive optical, and photonic cavity.

Original languageEnglish (US)
Pages (from-to)41-48
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2004
EventMicroarrays and Combinatorial Techniques: Design, Fabrication, and Analysis II - San Jose, CA, United States
Duration: Jan 25 2004Jan 26 2004


  • Adaptive optics
  • Antibody array
  • Bioassay
  • Biocd
  • High-speed
  • High-throughput
  • Immunoassay
  • Immunosensor
  • Interferometry
  • Microarray
  • Multi-analyte
  • Optical biosensor
  • Proteomics
  • Self-referencing

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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