Sphingosine kinase 1 is regulated by peroxisome proliferator-activated receptor α in response to free fatty acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity

Jessica S. Ross; Wei Hu; Bess Rosen; Ashley J. Snider; Lina M. Obeid; L. Ashley Cowart

doi:10.1074/jbc.M113.477786

Sphingosine kinase 1 is regulated by peroxisome proliferator-activated receptor α in response to free fatty acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity

Jessica S. Ross, Wei Hu, Bess Rosen, Ashley J. Snider, Lina M. Obeid, L. Ashley Cowart

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Background: The fatty acid palmitate induces sphingosine kinase 1 (Sphk1) activity in skeletal muscle by an unknown mechanism. Results: SphK1 is transcriptionally up-regulated by peroxisome proliferator-activated receptor α in lipid overload and promotes interleukin (IL)-6 expression and signaling. Conclusion: Palmitate-induced IL-6 is SphK1-dependent and mediates paracrine/autocrine IL-6 signaling in muscle. Significance: This study identifies a novel role for SphK1 in the context of obesity.

Original language	English (US)
Pages (from-to)	22193-22206
Number of pages	14
Journal	Journal of Biological Chemistry
Volume	288
Issue number	31
DOIs	https://doi.org/10.1074/jbc.M113.477786
State	Published - Aug 2 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Ross, J. S., Hu, W., Rosen, B., Snider, A. J., Obeid, L. M., & Cowart, L. A. (2013). Sphingosine kinase 1 is regulated by peroxisome proliferator-activated receptor α in response to free fatty acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity. Journal of Biological Chemistry, 288(31), 22193-22206. https://doi.org/10.1074/jbc.M113.477786

Sphingosine kinase 1 is regulated by peroxisome proliferator-activated receptor α in response to free fatty acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity. / Ross, Jessica S.; Hu, Wei; Rosen, Bess; Snider, Ashley J.; Obeid, Lina M.; Cowart, L. Ashley.

In: Journal of Biological Chemistry, Vol. 288, No. 31, 02.08.2013, p. 22193-22206.

Research output: Contribution to journal › Article › peer-review

Ross, JS, Hu, W, Rosen, B, Snider, AJ, Obeid, LM & Cowart, LA 2013, 'Sphingosine kinase 1 is regulated by peroxisome proliferator-activated receptor α in response to free fatty acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity', Journal of Biological Chemistry, vol. 288, no. 31, pp. 22193-22206. https://doi.org/10.1074/jbc.M113.477786

Ross JS, Hu W, Rosen B, Snider AJ, Obeid LM, Cowart LA. Sphingosine kinase 1 is regulated by peroxisome proliferator-activated receptor α in response to free fatty acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity. Journal of Biological Chemistry. 2013 Aug 2;288(31):22193-22206. https://doi.org/10.1074/jbc.M113.477786

Ross, Jessica S. ; Hu, Wei ; Rosen, Bess ; Snider, Ashley J. ; Obeid, Lina M. ; Cowart, L. Ashley. / Sphingosine kinase 1 is regulated by peroxisome proliferator-activated receptor α in response to free fatty acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 31. pp. 22193-22206.

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abstract = "Background: The fatty acid palmitate induces sphingosine kinase 1 (Sphk1) activity in skeletal muscle by an unknown mechanism. Results: SphK1 is transcriptionally up-regulated by peroxisome proliferator-activated receptor α in lipid overload and promotes interleukin (IL)-6 expression and signaling. Conclusion: Palmitate-induced IL-6 is SphK1-dependent and mediates paracrine/autocrine IL-6 signaling in muscle. Significance: This study identifies a novel role for SphK1 in the context of obesity.",

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Sphingosine kinase 1 is regulated by peroxisome proliferator-activated receptor α in response to free fatty acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity

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