Sphingosine kinase 1 is regulated by peroxisome proliferator-activated receptor α in response to free fatty acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity

Jessica S. Ross, Wei Hu, Bess Rosen, Ashley J. Snider, Lina M. Obeid, L. Ashley Cowart

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Background: The fatty acid palmitate induces sphingosine kinase 1 (Sphk1) activity in skeletal muscle by an unknown mechanism. Results: SphK1 is transcriptionally up-regulated by peroxisome proliferator-activated receptor α in lipid overload and promotes interleukin (IL)-6 expression and signaling. Conclusion: Palmitate-induced IL-6 is SphK1-dependent and mediates paracrine/autocrine IL-6 signaling in muscle. Significance: This study identifies a novel role for SphK1 in the context of obesity.

Original languageEnglish (US)
Pages (from-to)22193-22206
Number of pages14
JournalJournal of Biological Chemistry
Volume288
Issue number31
DOIs
StatePublished - Aug 2 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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