Sphingolipids in intestinal inflammation and tumorigenesis

Mónica García-Barros, Nicolas Coant, Ashley J. Snider

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Sphingolipids, and their metabolizing enzymes, have emerged as significant players in cell signaling and biology. These bioactive lipids function not only as structural lipids in cell, but mediate significant biologic functions as well. Sphingolipid enzymes function in the intestinal lumen to degrade exogenous dietary sphingolipids and in the enterocytes themselves to generate endogenous sphingolipids. Among the most studied bioactive sphingolipids are ceramide, sphingosine, and sphingosine-1-phosphate. These sphingolipids and their synthetic enzymes have been extensively implicated in intestinal inflammation and tumorigenesis and will be the focus of this chapter.

Original languageEnglish (US)
Title of host publicationIntestinal Tumorigenesis: Mechanisms of Development & Progression
PublisherSpringer International Publishing
Pages257-286
Number of pages30
ISBN (Electronic)9783319199863
ISBN (Print)9783319199856
DOIs
StatePublished - Sep 19 2015
Externally publishedYes

Keywords

  • Ceramide
  • Colitis
  • Colon cancer
  • Sphingolipid
  • Sphingomyelinase
  • Sphingosine
  • Sphingosine kinase
  • Sphingosine-1-phosphate

ASJC Scopus subject areas

  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology

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