Sphingolipids in intestinal inflammation and tumorigenesis

Mónica García-Barros; Nicolas Coant; Ashley J. Snider

doi:10.1007/978-3-319-19986-3_9

Sphingolipids in intestinal inflammation and tumorigenesis

Mónica García-Barros, Nicolas Coant, Ashley J. Snider

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Sphingolipids, and their metabolizing enzymes, have emerged as significant players in cell signaling and biology. These bioactive lipids function not only as structural lipids in cell, but mediate significant biologic functions as well. Sphingolipid enzymes function in the intestinal lumen to degrade exogenous dietary sphingolipids and in the enterocytes themselves to generate endogenous sphingolipids. Among the most studied bioactive sphingolipids are ceramide, sphingosine, and sphingosine-1-phosphate. These sphingolipids and their synthetic enzymes have been extensively implicated in intestinal inflammation and tumorigenesis and will be the focus of this chapter.

Original language	English (US)
Title of host publication	Intestinal Tumorigenesis: Mechanisms of Development & Progression
Publisher	Springer International Publishing
Pages	257-286
Number of pages	30
ISBN (Electronic)	9783319199863
ISBN (Print)	9783319199856
DOIs	https://doi.org/10.1007/978-3-319-19986-3_9
State	Published - Sep 19 2015
Externally published	Yes

Keywords

Ceramide
Colitis
Colon cancer
Sphingolipid
Sphingomyelinase
Sphingosine
Sphingosine kinase
Sphingosine-1-phosphate

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1007/978-3-319-19986-3_9

Cite this

@inbook{047b1338b9574cc19c9cb5aca5c2c098,

title = "Sphingolipids in intestinal inflammation and tumorigenesis",

abstract = "Sphingolipids, and their metabolizing enzymes, have emerged as significant players in cell signaling and biology. These bioactive lipids function not only as structural lipids in cell, but mediate significant biologic functions as well. Sphingolipid enzymes function in the intestinal lumen to degrade exogenous dietary sphingolipids and in the enterocytes themselves to generate endogenous sphingolipids. Among the most studied bioactive sphingolipids are ceramide, sphingosine, and sphingosine-1-phosphate. These sphingolipids and their synthetic enzymes have been extensively implicated in intestinal inflammation and tumorigenesis and will be the focus of this chapter.",

keywords = "Ceramide, Colitis, Colon cancer, Sphingolipid, Sphingomyelinase, Sphingosine, Sphingosine kinase, Sphingosine-1-phosphate",

author = "M{\'o}nica Garc{\'i}a-Barros and Nicolas Coant and Snider, {Ashley J.}",

year = "2015",

month = sep,

day = "19",

doi = "10.1007/978-3-319-19986-3_9",

language = "English (US)",

isbn = "9783319199856",

pages = "257--286",

booktitle = "Intestinal Tumorigenesis: Mechanisms of Development & Progression",

publisher = "Springer International Publishing",

}

TY - CHAP

T1 - Sphingolipids in intestinal inflammation and tumorigenesis

AU - García-Barros, Mónica

AU - Coant, Nicolas

AU - Snider, Ashley J.

PY - 2015/9/19

Y1 - 2015/9/19

N2 - Sphingolipids, and their metabolizing enzymes, have emerged as significant players in cell signaling and biology. These bioactive lipids function not only as structural lipids in cell, but mediate significant biologic functions as well. Sphingolipid enzymes function in the intestinal lumen to degrade exogenous dietary sphingolipids and in the enterocytes themselves to generate endogenous sphingolipids. Among the most studied bioactive sphingolipids are ceramide, sphingosine, and sphingosine-1-phosphate. These sphingolipids and their synthetic enzymes have been extensively implicated in intestinal inflammation and tumorigenesis and will be the focus of this chapter.

AB - Sphingolipids, and their metabolizing enzymes, have emerged as significant players in cell signaling and biology. These bioactive lipids function not only as structural lipids in cell, but mediate significant biologic functions as well. Sphingolipid enzymes function in the intestinal lumen to degrade exogenous dietary sphingolipids and in the enterocytes themselves to generate endogenous sphingolipids. Among the most studied bioactive sphingolipids are ceramide, sphingosine, and sphingosine-1-phosphate. These sphingolipids and their synthetic enzymes have been extensively implicated in intestinal inflammation and tumorigenesis and will be the focus of this chapter.

KW - Ceramide

KW - Colitis

KW - Colon cancer

KW - Sphingolipid

KW - Sphingomyelinase

KW - Sphingosine

KW - Sphingosine kinase

KW - Sphingosine-1-phosphate

UR - http://www.scopus.com/inward/record.url?scp=84955759120&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955759120&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-19986-3_9

DO - 10.1007/978-3-319-19986-3_9

M3 - Chapter

AN - SCOPUS:84955759120

SN - 9783319199856

SP - 257

EP - 286

BT - Intestinal Tumorigenesis: Mechanisms of Development & Progression

PB - Springer International Publishing

ER -

Sphingolipids in intestinal inflammation and tumorigenesis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this