TY - JOUR
T1 - Sphingolipids in colon cancer
AU - García-Barros, Mónica
AU - Coant, Nicolas
AU - Truman, Jean Philip
AU - Snider, Ashley J.
AU - Hannun, Yusuf A.
N1 - Funding Information:
This work was supported by the National Institutes of Health grant CA097132 . We would like to thank J-P Laigneau for the art work in Fig. 1 .
PY - 2014/5
Y1 - 2014/5
N2 - Colorectal cancer is one of the major causes of death in the western world. Despite increasing knowledge of the molecular signaling pathways implicated in colon cancer, therapeutic outcomes are still only moderately successful. Sphingolipids, a family of N-acyl linked lipids, have not only structural functions but are also implicated in important biological functions. Ceramide, sphingosine and sphingosine-1-phosphate are the most important bioactive lipids, and they regulate several key cellular functions. Accumulating evidence suggests that many cancers present alterations in sphingolipids and their metabolizing enzymes. The aim of this review is to discuss the emerging roles of sphingolipids, both endogenous and dietary, in colon cancer and the interaction of sphingolipids with WNT/β-catenin pathway, one of the most important signaling cascades that regulate development and homeostasis in intestine. This article is part of a Special Issue entitled New Frontiers in Sphingolipid Biology.
AB - Colorectal cancer is one of the major causes of death in the western world. Despite increasing knowledge of the molecular signaling pathways implicated in colon cancer, therapeutic outcomes are still only moderately successful. Sphingolipids, a family of N-acyl linked lipids, have not only structural functions but are also implicated in important biological functions. Ceramide, sphingosine and sphingosine-1-phosphate are the most important bioactive lipids, and they regulate several key cellular functions. Accumulating evidence suggests that many cancers present alterations in sphingolipids and their metabolizing enzymes. The aim of this review is to discuss the emerging roles of sphingolipids, both endogenous and dietary, in colon cancer and the interaction of sphingolipids with WNT/β-catenin pathway, one of the most important signaling cascades that regulate development and homeostasis in intestine. This article is part of a Special Issue entitled New Frontiers in Sphingolipid Biology.
KW - Ceramide
KW - Colorectal cancer
KW - Dietary
KW - Sphingolipids
KW - Sphingosine
KW - Sphingosine-1-phosphate
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U2 - 10.1016/j.bbalip.2013.09.007
DO - 10.1016/j.bbalip.2013.09.007
M3 - Review article
C2 - 24060581
AN - SCOPUS:84897954300
SN - 1388-1981
VL - 1841
SP - 773
EP - 782
JO - BBA - Specialised Section On Lipids and Related Subjects
JF - BBA - Specialised Section On Lipids and Related Subjects
IS - 5
ER -