Spectrophotometric determination of acidity constants of 4- dedimethylamino sancycline (Col-3), a new antitumor drug

Sirirat Pinsuwan; Fernando A. Alvarez-Núñez; S. Esmail Tabibi; S. H. Yalkowsky

doi:10.1021/js980398l

Spectrophotometric determination of acidity constants of 4- dedimethylamino sancycline (Col-3), a new antitumor drug

Sirirat Pinsuwan, Fernando A. Alvarez-Núñez, S. Esmail Tabibi, S. H. Yalkowsky

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

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Abstract

A spectrophotometric technique was used to determine the acidity constants of 4-dedimethylamino sancycline (Col-3), a new antitumor drug. The apparent pK(a) values of Col-3 in 0.5% methanol aqueous media at approximately 25 °C with a constant ionic strength of 0.2 were calculated manually and graphically to be 5.64 ± 0.17 (pK(a1)) and 8.35 ± 0.07 (pK(a2)). In addition, the computer program SQUAD was used to confirm Col-3 pK(a) values. The pK(a) values obtained by SQUAD were pK(a1) 5.63 ± 0.14 and pK(a2) 8.39 ± 0.04. These results are in agreement with the tetracycline- like structure of Col-3.

Original language	English (US)
Pages (from-to)	535-537
Number of pages	3
Journal	Journal of pharmaceutical sciences
Volume	88
Issue number	5
DOIs	https://doi.org/10.1021/js980398l
State	Published - May 1999

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Pharmaceutical Science

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@article{a9f232b2fb7e470f9978988d590a1fff,

title = "Spectrophotometric determination of acidity constants of 4- dedimethylamino sancycline (Col-3), a new antitumor drug",

abstract = "A spectrophotometric technique was used to determine the acidity constants of 4-dedimethylamino sancycline (Col-3), a new antitumor drug. The apparent pK(a) values of Col-3 in 0.5% methanol aqueous media at approximately 25 °C with a constant ionic strength of 0.2 were calculated manually and graphically to be 5.64 ± 0.17 (pK(a1)) and 8.35 ± 0.07 (pK(a2)). In addition, the computer program SQUAD was used to confirm Col-3 pK(a) values. The pK(a) values obtained by SQUAD were pK(a1) 5.63 ± 0.14 and pK(a2) 8.39 ± 0.04. These results are in agreement with the tetracycline- like structure of Col-3.",

author = "Sirirat Pinsuwan and Alvarez-N{\'u}{\~n}ez, {Fernando A.} and Tabibi, {S. Esmail} and Yalkowsky, {S. H.}",

note = "Funding Information: This work was performed in part under NCI contract no. CM-77109. We thank the CONACYT and the UNAM of M{\'e}xico. Also, the work of Dr. Alberto Rojas-Hern{\'a}ndez and Ms. Mi Jin Kim is appreciated.",

year = "1999",

month = may,

doi = "10.1021/js980398l",

language = "English (US)",

volume = "88",

pages = "535--537",

journal = "Journal of pharmaceutical sciences",

issn = "0022-3549",

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number = "5",

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T1 - Spectrophotometric determination of acidity constants of 4- dedimethylamino sancycline (Col-3), a new antitumor drug

AU - Pinsuwan, Sirirat

AU - Alvarez-Núñez, Fernando A.

AU - Tabibi, S. Esmail

AU - Yalkowsky, S. H.

N1 - Funding Information: This work was performed in part under NCI contract no. CM-77109. We thank the CONACYT and the UNAM of México. Also, the work of Dr. Alberto Rojas-Hernández and Ms. Mi Jin Kim is appreciated.

PY - 1999/5

Y1 - 1999/5

N2 - A spectrophotometric technique was used to determine the acidity constants of 4-dedimethylamino sancycline (Col-3), a new antitumor drug. The apparent pK(a) values of Col-3 in 0.5% methanol aqueous media at approximately 25 °C with a constant ionic strength of 0.2 were calculated manually and graphically to be 5.64 ± 0.17 (pK(a1)) and 8.35 ± 0.07 (pK(a2)). In addition, the computer program SQUAD was used to confirm Col-3 pK(a) values. The pK(a) values obtained by SQUAD were pK(a1) 5.63 ± 0.14 and pK(a2) 8.39 ± 0.04. These results are in agreement with the tetracycline- like structure of Col-3.

AB - A spectrophotometric technique was used to determine the acidity constants of 4-dedimethylamino sancycline (Col-3), a new antitumor drug. The apparent pK(a) values of Col-3 in 0.5% methanol aqueous media at approximately 25 °C with a constant ionic strength of 0.2 were calculated manually and graphically to be 5.64 ± 0.17 (pK(a1)) and 8.35 ± 0.07 (pK(a2)). In addition, the computer program SQUAD was used to confirm Col-3 pK(a) values. The pK(a) values obtained by SQUAD were pK(a1) 5.63 ± 0.14 and pK(a2) 8.39 ± 0.04. These results are in agreement with the tetracycline- like structure of Col-3.

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Spectrophotometric determination of acidity constants of 4- dedimethylamino sancycline (Col-3), a new antitumor drug

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