Specific Binding Sites for Atrial Natriuretic Factor in the Human Kidney

Christopher R. Mantyh, Nicholas C. Brecha, Patrick Soon-Shiong, Patrick W. Mantyh

Research output: Contribution to journalLetterpeer-review

10 Scopus citations


To the Editor: Several atrial natriuretic factors (ANFs) have been identified in the mammalian atria and have been shown to possess potent natriuretic, diuretic, and vasorelaxant activities in several species.1 Previous studies have demonstrated that ANF-like immunoreactivity is present in the human right atrium,2 and the gene encoding the human ANF (hANF) has been identified.3 However, specific binding sites for hANF and the physiologic response that occurs upon activation of these ANF binding sites has yet to be elucidated in human beings. We have studied the distribution of specific ANF binding sites in the human kidney. This distribution is the.

Original languageEnglish (US)
Pages (from-to)1710
Number of pages1
JournalNew England Journal of Medicine
Issue number26
StatePublished - Jun 27 1985

ASJC Scopus subject areas

  • General Medicine


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