TY - JOUR
T1 - Special Considerations for Supportive Care and Management of Complications in Elderly Patients With Multiple Myeloma
AU - George, Laeth L.
AU - Malik, Mustafa N.
AU - Miller, Eric J.
AU - Hicks, Kayla
AU - Khanam, Razwana
AU - Saterehaseman, Alireza
AU - McNichol, Megan
AU - Anwer, Faiz
N1 - Funding Information:
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/12
Y1 - 2021/12
N2 - Multiple myeloma is a progressive and incurable hematologic malignancy. It is predominantly a disease of older individuals, with a third of these patients considered to be elderly. In recent years, there has been a focus and emphasis on identifying and stratifying patients based on their functional status and frailty. There are several hallmark complications of the disease—hypercalcemia, renal insufficiency, anemia, bone pain—along with thromboembolism and compromised immunity that are common in patients with multiple myeloma. Due to the wide range of patient ages and functional status, there are, accordingly, different considerations for management of the above complications based on numerous factors, including frailty status. This review focuses on considerations and management of common complications of multiple myeloma in elderly patients. These include renal failure, skeletal complications, anemia, thromboembolism, and infectious complications.
AB - Multiple myeloma is a progressive and incurable hematologic malignancy. It is predominantly a disease of older individuals, with a third of these patients considered to be elderly. In recent years, there has been a focus and emphasis on identifying and stratifying patients based on their functional status and frailty. There are several hallmark complications of the disease—hypercalcemia, renal insufficiency, anemia, bone pain—along with thromboembolism and compromised immunity that are common in patients with multiple myeloma. Due to the wide range of patient ages and functional status, there are, accordingly, different considerations for management of the above complications based on numerous factors, including frailty status. This review focuses on considerations and management of common complications of multiple myeloma in elderly patients. These include renal failure, skeletal complications, anemia, thromboembolism, and infectious complications.
KW - Anemia
KW - Bone
KW - Frail
KW - Infection
KW - Renal Failure
KW - Thromboembolism
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U2 - 10.1016/j.clml.2021.07.013
DO - 10.1016/j.clml.2021.07.013
M3 - Review article
C2 - 34384735
AN - SCOPUS:85113165524
SN - 2152-2650
VL - 21
SP - 812
EP - 822
JO - Clinical Lymphoma, Myeloma and Leukemia
JF - Clinical Lymphoma, Myeloma and Leukemia
IS - 12
ER -