Abstract
The objective of this study was to develop a technique for analyzing spatial patterns of cartilage loss in the medial femoral condyle (MF), and to study MF cartilage loss in participants of the Osteoarthritis Initiative. Using a 0.7mm sagittal double echo at steady state (DESS) sequence, 160 osteoarthritic knees from 80 participants with varying degrees of medial joint space narrowing were imaged at baseline and 1-year follow-up. MF cartilage was segmented and cartilage loss determined. Rate of change varied significantly (P = 0.0067) along the anterior-posterior extension of the MF, with the greatest changes (-45 μm, -2.7%) observed 30-60° posterior to the trochlear notch. The rate was greater in the central MF after excluding peripheral aspects of the MF from analysis. Sensitivity to change was greatest at 45-75° (standardized response mean = -0.32) but was minimally affected by medial-lateral trimming. In conclusion, the greatest sensitivity to change was achieved when analyzing the posterior aspect of the central, weight-bearing MF.
Original language | English (US) |
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Pages (from-to) | 574-581 |
Number of pages | 8 |
Journal | Magnetic Resonance in Medicine |
Volume | 63 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2010 |
Keywords
- 3 tesla
- Cartilage
- Image analysis
- Osteoarthritis
- Subregions
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging