Sparsity-driven ideal observer for computed medical imaging systems

Kun Wang, Yang Lou, Matthew A. Kupinski, Mark A. Anastasio

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations


The Bayesian ideal observer (IO) has been widely advocated to guide hardware optimization. However, except for special cases, computation of the IO test statistic is computationally burdensome and requires an appropriate stochastic object model that may be difficult to determine in practice. Modern reconstruction methods, referred to as sparse reconstruction methods, exploit the fact that objects of interest typically possess sparse representations and have proven to be highly effective at reconstructing images from under-sampled measurement data. Moreover, in computed imaging approaches that employ compressive sensing concepts, imaging hardware and image reconstruction are innately coupled technologies. In this work, we propose a sparsity-driven IO (SD-IO) to guide the optimization of data acquisition parameters for modern computed imaging systems. The SD-IO employs a variational Bayesian inference method to estimate the posterior distribution and calculates an approximate likelihood ratio analytically as its test statistic. Since it assumes knowledge of low-level statistical properties of the object that are related to sparsity, the SD-IO exploits the same statistical information regarding the object that is utilized by highly effective sparse image reconstruction methods. Preliminary simulation results are presented to demonstrate the feasibility of the SD-IO calculation.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2015
Subtitle of host publicationImage Perception, Observer Performance, and Technology Assessment
EditorsClaudia R. Mello-Thoms, Matthew A. Kupinski, Claudia R. Mello-Thoms
ISBN (Electronic)9781628415063
StatePublished - 2015
EventMedical Imaging 2015: Image Perception, Observer Performance, and Technology Assessment - Orlando, United States
Duration: Feb 25 2015Feb 26 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2015: Image Perception, Observer Performance, and Technology Assessment
Country/TerritoryUnited States

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging
  • Biomaterials


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