Soy diet worsens heart disease in mice

Brian L. Stauffer, John P. Konhilas, Elizabeth D. Luczak, Leslie A. Leinwand

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


We report that dietary modification from a soy-based diet to a casein-based diet radically improves disease indicators and cardiac function in a transgenic mouse model of hypertrophic cardiomyopathy. On a soy diet, males with a mutation in the α-myosin heavy chain gene progress to dilation and heart failure. However, males fed a casein diet no longer deteriorate to severe, dilated cardiomyopathy. Remarkably, their LV size and contractile function are preserved. Further, this diet prevents a number of pathologic indicators in males, including fibrosis, induction of β-myosin heavy chain, inactivation of glycogen synthase kinase 3β (GSK3β), and caspase-3 activation.

Original languageEnglish (US)
Pages (from-to)209-216
Number of pages8
JournalJournal of Clinical Investigation
Issue number1
StatePublished - Jan 2006

ASJC Scopus subject areas

  • General Medicine


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