Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume

David J. Madden; Emily L. Parks; Catherine W. Tallman; Maria A. Boylan; David A. Hoagey; Sally B. Cocjin; Lauren E. Packard; Micah A. Johnson; Ying hui Chou; Guy G. Potter; Nan kuei Chen; Rachel E. Siciliano; Zachary A. Monge; Jesse A. Honig; Michele T. Diaz

doi:10.1016/j.neurobiolaging.2017.01.027

Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume

David J. Madden, Emily L. Parks, Catherine W. Tallman, Maria A. Boylan, David A. Hoagey, Sally B. Cocjin, Lauren E. Packard, Micah A. Johnson, Ying hui Chou, Guy G. Potter, Nan kuei Chen, Rachel E. Siciliano, Zachary A. Monge, Jesse A. Honig, Michele T. Diaz

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Age-related decline in fluid cognition can be characterized as a disconnection among specific brain structures, leading to a decline in functional efficiency. The potential sources of disconnection, however, are unclear. We investigated imaging measures of cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume as mediators of the relation between age and fluid cognition, in 145 healthy, community-dwelling adults 19–79 years of age. At a general level of analysis, with a single composite measure of fluid cognition and single measures of each of the 3 imaging modalities, age exhibited an independent influence on the cognitive and imaging measures, and the imaging variables did not mediate the age-cognition relation. At a more specific level of analysis, resting-state functional connectivity of sensorimotor networks was a significant mediator of the age-related decline in executive function. These findings suggest that different levels of analysis lead to different models of neurocognitive disconnection, and that resting-state functional connectivity, in particular, may contribute to age-related decline in executive function.

Original language	English (US)
Pages (from-to)	199-213
Number of pages	15
Journal	Neurobiology of Aging
Volume	54
DOIs	https://doi.org/10.1016/j.neurobiolaging.2017.01.027
State	Published - Jun 1 2017
Externally published	Yes

Keywords

Cognition
Cortex
Diffusion tensor imaging
Magnetic resonance imaging
Mediation

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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Madden, D. J., Parks, E. L., Tallman, C. W., Boylan, M. A., Hoagey, D. A., Cocjin, S. B., Packard, L. E., Johnson, M. A., Chou, Y. H., Potter, G. G., Chen, N. K., Siciliano, R. E., Monge, Z. A., Honig, J. A., & Diaz, M. T. (2017). Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume. Neurobiology of Aging, 54, 199-213. https://doi.org/10.1016/j.neurobiolaging.2017.01.027

Madden, DJ, Parks, EL, Tallman, CW, Boylan, MA, Hoagey, DA, Cocjin, SB, Packard, LE, Johnson, MA, Chou, YH, Potter, GG, Chen, NK, Siciliano, RE, Monge, ZA, Honig, JA & Diaz, MT 2017, 'Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume', Neurobiology of Aging, vol. 54, pp. 199-213. https://doi.org/10.1016/j.neurobiolaging.2017.01.027

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title = "Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume",

abstract = "Age-related decline in fluid cognition can be characterized as a disconnection among specific brain structures, leading to a decline in functional efficiency. The potential sources of disconnection, however, are unclear. We investigated imaging measures of cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume as mediators of the relation between age and fluid cognition, in 145 healthy, community-dwelling adults 19–79 years of age. At a general level of analysis, with a single composite measure of fluid cognition and single measures of each of the 3 imaging modalities, age exhibited an independent influence on the cognitive and imaging measures, and the imaging variables did not mediate the age-cognition relation. At a more specific level of analysis, resting-state functional connectivity of sensorimotor networks was a significant mediator of the age-related decline in executive function. These findings suggest that different levels of analysis lead to different models of neurocognitive disconnection, and that resting-state functional connectivity, in particular, may contribute to age-related decline in executive function.",

keywords = "Cognition, Cortex, Diffusion tensor imaging, Magnetic resonance imaging, Mediation",

author = "Madden, {David J.} and Parks, {Emily L.} and Tallman, {Catherine W.} and Boylan, {Maria A.} and Hoagey, {David A.} and Cocjin, {Sally B.} and Packard, {Lauren E.} and Johnson, {Micah A.} and Chou, {Ying hui} and Potter, {Guy G.} and Chen, {Nan kuei} and Siciliano, {Rachel E.} and Monge, {Zachary A.} and Honig, {Jesse A.} and Diaz, {Michele T.}",

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doi = "10.1016/j.neurobiolaging.2017.01.027",

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T2 - cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume

AU - Madden, David J.

AU - Parks, Emily L.

AU - Tallman, Catherine W.

AU - Boylan, Maria A.

AU - Hoagey, David A.

AU - Cocjin, Sally B.

AU - Packard, Lauren E.

AU - Johnson, Micah A.

AU - Chou, Ying hui

AU - Potter, Guy G.

AU - Chen, Nan kuei

AU - Siciliano, Rachel E.

AU - Monge, Zachary A.

AU - Honig, Jesse A.

AU - Diaz, Michele T.

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Y1 - 2017/6/1

N2 - Age-related decline in fluid cognition can be characterized as a disconnection among specific brain structures, leading to a decline in functional efficiency. The potential sources of disconnection, however, are unclear. We investigated imaging measures of cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume as mediators of the relation between age and fluid cognition, in 145 healthy, community-dwelling adults 19–79 years of age. At a general level of analysis, with a single composite measure of fluid cognition and single measures of each of the 3 imaging modalities, age exhibited an independent influence on the cognitive and imaging measures, and the imaging variables did not mediate the age-cognition relation. At a more specific level of analysis, resting-state functional connectivity of sensorimotor networks was a significant mediator of the age-related decline in executive function. These findings suggest that different levels of analysis lead to different models of neurocognitive disconnection, and that resting-state functional connectivity, in particular, may contribute to age-related decline in executive function.

AB - Age-related decline in fluid cognition can be characterized as a disconnection among specific brain structures, leading to a decline in functional efficiency. The potential sources of disconnection, however, are unclear. We investigated imaging measures of cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume as mediators of the relation between age and fluid cognition, in 145 healthy, community-dwelling adults 19–79 years of age. At a general level of analysis, with a single composite measure of fluid cognition and single measures of each of the 3 imaging modalities, age exhibited an independent influence on the cognitive and imaging measures, and the imaging variables did not mediate the age-cognition relation. At a more specific level of analysis, resting-state functional connectivity of sensorimotor networks was a significant mediator of the age-related decline in executive function. These findings suggest that different levels of analysis lead to different models of neurocognitive disconnection, and that resting-state functional connectivity, in particular, may contribute to age-related decline in executive function.

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Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume

Abstract

Keywords

ASJC Scopus subject areas

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