Sorbifolivaltrates A-D, diene valepotriates from Valeriana sorbifolia

Ya Ming Xu; Steven P. McLaughlin; A. A.Leslie Gunatilaka

doi:10.1021/np0704553

Sorbifolivaltrates A-D, diene valepotriates from Valeriana sorbifolia

Ya Ming Xu
, Steven P. McLaughlin
, A. A.Leslie Gunatilaka

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Four new diene valepotriates, sorbifolivaltrates A-D (1-4), and the known compounds isovaltrate (5), valtrate (6), seneciovaltrate (7), valtrate hydrine B3 (8), and valtrate hydrine B7 (9), have been isolated by bioassay-guided fractionation of the cytotoxic hexanes and methyl ethyl ketone crude extracts of the aerial parts of Valeriana sorbifolia occurring in the Sonoran desert. The structures of 1-4 were determined on the basis of their high-resolution mass spectrometric and NMR spectroscopic data. All compounds exhibited weak to moderate cytotoxicity against the human metastatic prostate cancer cell line, PC-3M.

Original language	English (US)
Pages (from-to)	2045-2048
Number of pages	4
Journal	Journal Of Natural Products
Volume	70
Issue number	12
DOIs	https://doi.org/10.1021/np0704553
State	Published - Dec 2007

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

10.1021/np0704553

Cite this

@article{49d86946587d4dd58a97ee952cf065e8,

title = "Sorbifolivaltrates A-D, diene valepotriates from Valeriana sorbifolia",

abstract = "Four new diene valepotriates, sorbifolivaltrates A-D (1-4), and the known compounds isovaltrate (5), valtrate (6), seneciovaltrate (7), valtrate hydrine B3 (8), and valtrate hydrine B7 (9), have been isolated by bioassay-guided fractionation of the cytotoxic hexanes and methyl ethyl ketone crude extracts of the aerial parts of Valeriana sorbifolia occurring in the Sonoran desert. The structures of 1-4 were determined on the basis of their high-resolution mass spectrometric and NMR spectroscopic data. All compounds exhibited weak to moderate cytotoxicity against the human metastatic prostate cancer cell line, PC-3M.",

author = "Xu, \{Ya Ming\} and McLaughlin, \{Steven P.\} and Gunatilaka, \{A. A.Leslie\}",

year = "2007",

month = dec,

doi = "10.1021/np0704553",

language = "English (US)",

volume = "70",

pages = "2045--2048",

journal = "Journal Of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "12",

}

TY - JOUR

T1 - Sorbifolivaltrates A-D, diene valepotriates from Valeriana sorbifolia

AU - Xu, Ya Ming

AU - McLaughlin, Steven P.

AU - Gunatilaka, A. A.Leslie

PY - 2007/12

Y1 - 2007/12

N2 - Four new diene valepotriates, sorbifolivaltrates A-D (1-4), and the known compounds isovaltrate (5), valtrate (6), seneciovaltrate (7), valtrate hydrine B3 (8), and valtrate hydrine B7 (9), have been isolated by bioassay-guided fractionation of the cytotoxic hexanes and methyl ethyl ketone crude extracts of the aerial parts of Valeriana sorbifolia occurring in the Sonoran desert. The structures of 1-4 were determined on the basis of their high-resolution mass spectrometric and NMR spectroscopic data. All compounds exhibited weak to moderate cytotoxicity against the human metastatic prostate cancer cell line, PC-3M.

AB - Four new diene valepotriates, sorbifolivaltrates A-D (1-4), and the known compounds isovaltrate (5), valtrate (6), seneciovaltrate (7), valtrate hydrine B3 (8), and valtrate hydrine B7 (9), have been isolated by bioassay-guided fractionation of the cytotoxic hexanes and methyl ethyl ketone crude extracts of the aerial parts of Valeriana sorbifolia occurring in the Sonoran desert. The structures of 1-4 were determined on the basis of their high-resolution mass spectrometric and NMR spectroscopic data. All compounds exhibited weak to moderate cytotoxicity against the human metastatic prostate cancer cell line, PC-3M.

UR - https://www.scopus.com/pages/publications/38349071952

UR - https://www.scopus.com/pages/publications/38349071952#tab=citedBy

U2 - 10.1021/np0704553

DO - 10.1021/np0704553

M3 - Article

C2 - 18052324

AN - SCOPUS:38349071952

SN - 0163-3864

VL - 70

SP - 2045

EP - 2048

JO - Journal Of Natural Products

JF - Journal Of Natural Products

IS - 12

ER -

Sorbifolivaltrates A-D, diene valepotriates from Valeriana sorbifolia

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this