Sorbifolivaltrates A-D, diene valepotriates from Valeriana sorbifolia

Ya Ming Xu; Steven P. McLaughlin; A. A.Leslie Gunatilaka

doi:10.1021/np0704553

Sorbifolivaltrates A-D, diene valepotriates from Valeriana sorbifolia

Ya Ming Xu, Steven P. McLaughlin, A. A.Leslie Gunatilaka

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Four new diene valepotriates, sorbifolivaltrates A-D (1-4), and the known compounds isovaltrate (5), valtrate (6), seneciovaltrate (7), valtrate hydrine B3 (8), and valtrate hydrine B7 (9), have been isolated by bioassay-guided fractionation of the cytotoxic hexanes and methyl ethyl ketone crude extracts of the aerial parts of Valeriana sorbifolia occurring in the Sonoran desert. The structures of 1-4 were determined on the basis of their high-resolution mass spectrometric and NMR spectroscopic data. All compounds exhibited weak to moderate cytotoxicity against the human metastatic prostate cancer cell line, PC-3M.

Original language	English (US)
Pages (from-to)	2045-2048
Number of pages	4
Journal	Journal Of Natural Products
Volume	70
Issue number	12
DOIs	https://doi.org/10.1021/np0704553
State	Published - Dec 2007

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np0704553

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abstract = "Four new diene valepotriates, sorbifolivaltrates A-D (1-4), and the known compounds isovaltrate (5), valtrate (6), seneciovaltrate (7), valtrate hydrine B3 (8), and valtrate hydrine B7 (9), have been isolated by bioassay-guided fractionation of the cytotoxic hexanes and methyl ethyl ketone crude extracts of the aerial parts of Valeriana sorbifolia occurring in the Sonoran desert. The structures of 1-4 were determined on the basis of their high-resolution mass spectrometric and NMR spectroscopic data. All compounds exhibited weak to moderate cytotoxicity against the human metastatic prostate cancer cell line, PC-3M.",

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Sorbifolivaltrates A-D, diene valepotriates from Valeriana sorbifolia

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