Sonothrombolysis in acute stroke and myocardial infarction: A systematic review

Sebastiaan S. Roos, Lynda M.L. Juffermans, Jeroen Slikkerveer, Evan C. Unger, Thomas R. Porter, Otto Kampa

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Introduction: Current treatment of patients with an acute occlusion of a cranial or a coronary artery, in for example ST segment elevation myocardial infarction (STEMI), consists of either thrombolysis or percutaneous intervention. Various thrombolytic agents (tissue plasminogen activators) are used for reperfusion therapy in patients with STEMI. However, their use may be associated with an increased risk of bleeding which is inherent to their actionmechanism. Therefore, newmethods of coronary clot resolution are being studied in an attempt to potentiate the efficacy and reduce the side effects of thrombolytics. A new method is ultrasound mediated thrombus dissolution, or sonothrombolysis. The current literature exploring sonothrombolysis is diverse in size and quality. In this systematic review of the current literature, we describe cardiovascular applications of sonothrombolysis in patients. A comparison to the neurovascular application in ischemic stroke is made, as more research has been performed on patients suffering from stroke. Methods: A systematic search was performed following the PRISMA guidelines using EMBASE and MEDLINE databases regarding sonothrombolysis in human ischemic stroke and acute myocardial infarction patients. Results: 12 original case-control or randomized controlled trials using a combination of ultrasound and microbubbles were found. 6 trials studied ischemic stroke, and 6 trials studied acute myocardial infarction. Conclusion: This systematic review provides up to date information on the subject of sonothrombolysis.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalIJC Heart and Vessels
Issue number1
StatePublished - 2014
Externally publishedYes


  • Coronary artery disease
  • Echocardiography
  • Ischemic stroke
  • Sonothrombolysis
  • Thromboembolic
  • Ultrasound contrast agents
  • events

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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