Solvent-free nitration of electron-rich arenes

Bhumasamudram Jagadish, Nathaniel R. Hurley, Eugene A. Mash

Research output: Contribution to journalArticlepeer-review


Nitration of relatively electron-rich arenes does not require an additive or a solvent. For example, reaction on a gram scale of anisole with acetyl nitrate, generated in situ by mixing 100% HNO3 with acetic anhydride, produced 2,4-dinitroanisole in 82% yield after crystallization of the crude product. Results with five additional monosubstituted benzene derivatives possessing highly activated, weakly activated, or weakly deactivated rings are reported.

Original languageEnglish (US)
Pages (from-to)2395-2398
Number of pages4
JournalSynthetic Communications
Issue number24
StatePublished - Dec 17 2017
Externally publishedYes


  • 2,4-Dinitroanisole
  • additive-free
  • nitration
  • solvent-free

ASJC Scopus subject areas

  • Organic Chemistry


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