Solubilization of rapamycin

Pahala Simamora; Joan M. Alvarez; Samuel H. Yalkowsky

doi:10.1016/S0378-5173(00)00617-7

Solubilization of rapamycin

Pahala Simamora, Joan M. Alvarez, Samuel H. Yalkowsky

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

182 Scopus citations

Abstract

The solubilization of rapamycin, a poorly water soluble investigational immunosuppressive drug, by facilitated hydrotropy is presented. Partially water-miscible aromatic solutes (such as benzyl alcohol, benzoate, or benzoic acid) can be solubilized by water-miscible cosolvents, such as ethanol and propylene glycol. Once solubilized, the partially miscible aromatic solute becomes a solubilizing agent. This technique yielded a dramatic (> 1000-fold) increase in the aqueous solubility of rapamycin.

Original language	English (US)
Pages (from-to)	25-29
Number of pages	5
Journal	International Journal of Pharmaceutics
Volume	213
Issue number	1-2
DOIs	https://doi.org/10.1016/S0378-5173(00)00617-7
State	Published - Feb 1 2001

Keywords

Cosolvent
Hydrotrope
Hydrotropy
Rapamycin
Solubility
Solubilization

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/S0378-5173(00)00617-7

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title = "Solubilization of rapamycin",

abstract = "The solubilization of rapamycin, a poorly water soluble investigational immunosuppressive drug, by facilitated hydrotropy is presented. Partially water-miscible aromatic solutes (such as benzyl alcohol, benzoate, or benzoic acid) can be solubilized by water-miscible cosolvents, such as ethanol and propylene glycol. Once solubilized, the partially miscible aromatic solute becomes a solubilizing agent. This technique yielded a dramatic (> 1000-fold) increase in the aqueous solubility of rapamycin.",

keywords = "Cosolvent, Hydrotrope, Hydrotropy, Rapamycin, Solubility, Solubilization",

author = "Pahala Simamora and Alvarez, {Joan M.} and Yalkowsky, {Samuel H.}",

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AU - Simamora, Pahala

AU - Alvarez, Joan M.

AU - Yalkowsky, Samuel H.

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N2 - The solubilization of rapamycin, a poorly water soluble investigational immunosuppressive drug, by facilitated hydrotropy is presented. Partially water-miscible aromatic solutes (such as benzyl alcohol, benzoate, or benzoic acid) can be solubilized by water-miscible cosolvents, such as ethanol and propylene glycol. Once solubilized, the partially miscible aromatic solute becomes a solubilizing agent. This technique yielded a dramatic (> 1000-fold) increase in the aqueous solubility of rapamycin.

AB - The solubilization of rapamycin, a poorly water soluble investigational immunosuppressive drug, by facilitated hydrotropy is presented. Partially water-miscible aromatic solutes (such as benzyl alcohol, benzoate, or benzoic acid) can be solubilized by water-miscible cosolvents, such as ethanol and propylene glycol. Once solubilized, the partially miscible aromatic solute becomes a solubilizing agent. This technique yielded a dramatic (> 1000-fold) increase in the aqueous solubility of rapamycin.

KW - Cosolvent

KW - Hydrotrope

KW - Hydrotropy

KW - Rapamycin

KW - Solubility

KW - Solubilization

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AN - SCOPUS:0035253757

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EP - 29

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -

Solubilization of rapamycin

Abstract

Keywords

ASJC Scopus subject areas

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