Abstract
The solubilization of rapamycin, a poorly water soluble investigational immunosuppressive drug, by facilitated hydrotropy is presented. Partially water-miscible aromatic solutes (such as benzyl alcohol, benzoate, or benzoic acid) can be solubilized by water-miscible cosolvents, such as ethanol and propylene glycol. Once solubilized, the partially miscible aromatic solute becomes a solubilizing agent. This technique yielded a dramatic (> 1000-fold) increase in the aqueous solubility of rapamycin.
Original language | English (US) |
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Pages (from-to) | 25-29 |
Number of pages | 5 |
Journal | International Journal of Pharmaceutics |
Volume | 213 |
Issue number | 1-2 |
DOIs | |
State | Published - Feb 1 2001 |
Keywords
- Cosolvent
- Hydrotrope
- Hydrotropy
- Rapamycin
- Solubility
- Solubilization
ASJC Scopus subject areas
- Pharmaceutical Science