Solubilization of Fluasterone in cosolvent/cyclodextrin combinations

Yan He; Ping Li; Samuel H. Yalkowsky

doi:10.1016/S0378-5173(03)00389-2

Solubilization of Fluasterone in cosolvent/cyclodextrin combinations

Yan He, Ping Li, Samuel H. Yalkowsky

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

The combined effect of cosolvent (methanol (MeOH), ethanol (EtOH), or n-propanol (n-PrOH)) and complexant hydroxypropyl-β-cyclodextrin (HPβCD) on the solubility of Fluasterone is evaluated and explained with a simple equation. The calculated constants in the equation not only quantitatively describe the dependence of drug solubility on cosolvent and ligand concentrations, but also explain the minima that are observed in the Fluasterone solubility versus cosolvent concentration curves at fixed HPβCD concentrations.

Original language	English (US)
Pages (from-to)	25-34
Number of pages	10
Journal	International Journal of Pharmaceutics
Volume	264
Issue number	1-2
DOIs	https://doi.org/10.1016/S0378-5173(03)00389-2
State	Published - Oct 2 2003

Keywords

Complexation
Cosolvent
Cyclodextrin
Fluasterone
Mixed solvent
Solubilization

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/S0378-5173(03)00389-2

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title = "Solubilization of Fluasterone in cosolvent/cyclodextrin combinations",

abstract = "The combined effect of cosolvent (methanol (MeOH), ethanol (EtOH), or n-propanol (n-PrOH)) and complexant hydroxypropyl-β-cyclodextrin (HPβCD) on the solubility of Fluasterone is evaluated and explained with a simple equation. The calculated constants in the equation not only quantitatively describe the dependence of drug solubility on cosolvent and ligand concentrations, but also explain the minima that are observed in the Fluasterone solubility versus cosolvent concentration curves at fixed HPβCD concentrations.",

keywords = "Complexation, Cosolvent, Cyclodextrin, Fluasterone, Mixed solvent, Solubilization",

author = "Yan He and Ping Li and Yalkowsky, {Samuel H.}",

year = "2003",

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doi = "10.1016/S0378-5173(03)00389-2",

language = "English (US)",

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T1 - Solubilization of Fluasterone in cosolvent/cyclodextrin combinations

AU - He, Yan

AU - Li, Ping

AU - Yalkowsky, Samuel H.

PY - 2003/10/2

Y1 - 2003/10/2

N2 - The combined effect of cosolvent (methanol (MeOH), ethanol (EtOH), or n-propanol (n-PrOH)) and complexant hydroxypropyl-β-cyclodextrin (HPβCD) on the solubility of Fluasterone is evaluated and explained with a simple equation. The calculated constants in the equation not only quantitatively describe the dependence of drug solubility on cosolvent and ligand concentrations, but also explain the minima that are observed in the Fluasterone solubility versus cosolvent concentration curves at fixed HPβCD concentrations.

AB - The combined effect of cosolvent (methanol (MeOH), ethanol (EtOH), or n-propanol (n-PrOH)) and complexant hydroxypropyl-β-cyclodextrin (HPβCD) on the solubility of Fluasterone is evaluated and explained with a simple equation. The calculated constants in the equation not only quantitatively describe the dependence of drug solubility on cosolvent and ligand concentrations, but also explain the minima that are observed in the Fluasterone solubility versus cosolvent concentration curves at fixed HPβCD concentrations.

KW - Complexation

KW - Cosolvent

KW - Cyclodextrin

KW - Fluasterone

KW - Mixed solvent

KW - Solubilization

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DO - 10.1016/S0378-5173(03)00389-2

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AN - SCOPUS:0142028207

SN - 0378-5173

VL - 264

SP - 25

EP - 34

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1-2

ER -

Solubilization of Fluasterone in cosolvent/cyclodextrin combinations

Abstract

Keywords

ASJC Scopus subject areas

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