TY - JOUR
T1 - Solubilization of fluasterone
AU - Zhao, Luwei
AU - Li, Ping
AU - Yalkowsky, Samuel H.
PY - 1999/10
Y1 - 1999/10
N2 - Solubilization of nonpolar drugs constitutes one of the most important tasks in parenteral formulations design. This study investigates and assesses the solubility enhancement of Fluasterone by various techniques including cosolvency, micellization, and complexation. Of the solubilizing agents used, the modified β-cyclodextrins were found to be the most effective. The solubility of Fluasterone is 1.55 x 10-4 mM, 3.13 mM, and 4.04 mM in water, 20% sulfobutyl ether-β-cyclodextrin (SBEβCD), and 20% hydroxypropyl-β- cyclodextrin (HPβCD), respectively.
AB - Solubilization of nonpolar drugs constitutes one of the most important tasks in parenteral formulations design. This study investigates and assesses the solubility enhancement of Fluasterone by various techniques including cosolvency, micellization, and complexation. Of the solubilizing agents used, the modified β-cyclodextrins were found to be the most effective. The solubility of Fluasterone is 1.55 x 10-4 mM, 3.13 mM, and 4.04 mM in water, 20% sulfobutyl ether-β-cyclodextrin (SBEβCD), and 20% hydroxypropyl-β- cyclodextrin (HPβCD), respectively.
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U2 - 10.1021/js9901413
DO - 10.1021/js9901413
M3 - Article
C2 - 10514340
AN - SCOPUS:0032834728
SN - 0022-3549
VL - 88
SP - 967
EP - 969
JO - Journal of pharmaceutical sciences
JF - Journal of pharmaceutical sciences
IS - 10
ER -