Solubilization by cosolvents I: Organic solutes in propylene glycol–water mixtures

S. H. Yalkowsky; Joseph T. Rubino

doi:10.1002/jps.2600740410

Solubilization by cosolvents I: Organic solutes in propylene glycol–water mixtures

S. H. Yalkowsky, Joseph T. Rubino

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

105 Scopus citations

Abstract

An equation describing solubilization in aqueous systems by cosolvents was developed by treating a mixed solvent as a linear combination of its components. This equation can successfully explain both the exponential increases and the exponential decreases in aqueous solubility that are frequently observed with the addition of cosolvent. It also provides a means of estimating to what extent a particular drug can be solubilized and how much cosolvent would be required to accomplish a particular degree of solubilization.

Original language	English (US)
Pages (from-to)	416-421
Number of pages	6
Journal	Journal of pharmaceutical sciences
Volume	74
Issue number	4
DOIs	https://doi.org/10.1002/jps.2600740410
State	Published - Apr 1985

ASJC Scopus subject areas

Pharmaceutical Science

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10.1002/jps.2600740410

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abstract = "An equation describing solubilization in aqueous systems by cosolvents was developed by treating a mixed solvent as a linear combination of its components. This equation can successfully explain both the exponential increases and the exponential decreases in aqueous solubility that are frequently observed with the addition of cosolvent. It also provides a means of estimating to what extent a particular drug can be solubilized and how much cosolvent would be required to accomplish a particular degree of solubilization.",

author = "Yalkowsky, {S. H.} and Rubino, {Joseph T.}",

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Solubilization by cosolvents I: Organic solutes in propylene glycol–water mixtures

Abstract

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