Solubility prediction in Octanol: A technical note

Kia Sepassi, Samuel H. Yalkowsky

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


The purpose of this work was to derive an equation for the rapid estimation of octanol solubilities of organic compounds. Solubilities ranging over 4 orders of magnitude were predicted with an average absolute error of 0.39 logarithmic units using melting point alone. The greatest error in prediction occurred for strongly bonded compounds.

Original languageEnglish (US)
Article number26
Pages (from-to)E1-E8
JournalAAPS PharmSciTech
Issue number1
StatePublished - Mar 24 2006


  • Activity coefficient
  • Octanol solubility
  • Solubility parameter

ASJC Scopus subject areas

  • Pharmaceutical Science


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