Abstract
The relative solubilities of n‐alkyl p‐ aminobenzoates in water, propylene glycol‐water mixtures, propylene glycol, and several other pharmaceutically important solvents can be predicted on the basis of a theoretical equation. This equation relates the activity coefficient of the hydrophobic portion of the molecule to the product of its surface area and its interfacial tension [free energy per unit area of a hydrocarbon (tetradecane) against the polar or semipolar solvent of interest]. The assumptions, conclusions, and applicability of the theoretical relationship are compared to those of the Scatchard‐Hildebrand approach.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 48-52 |
| Number of pages | 5 |
| Journal | Journal of pharmaceutical sciences |
| Volume | 64 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1975 |
| Externally published | Yes |
Keywords
- Alkyl p‐aminobenzoates—solubility in polar and mixed solvents, equation developed for predicting solubility
- Solubility—alkyl p‐aminobenzoates in polar and mixed solvents, equation developed for predicting solubility, compared to Scatchard‐Hildebrand approach
- Solvents, polar—solubility of nonelectrolytes (alkyl p‐aminobenzoates)
- p‐Aminobenzoates, alkyl—solubility in polar and mixed solvents, equation developed for predicting solubility
ASJC Scopus subject areas
- Pharmaceutical Science