Abstract
An expression for estimating the aqueous solubility of weak electrolytes under different conditions of temperature and pH has been proposed in a previous publication. The expression, based on the additivity of free energy, separates solubility into three independent contributions. In the present work, the equation is tested with a different set of 18 solutes within the range of temperature of 20 to 50 °C and of pH of 1 to 10. The results show that the theoretical relationship between aqueous solubility and the three independent contributions used in the equation is in excellent agreement with the experimental data.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 518-522 |
| Number of pages | 5 |
| Journal | Journal of pharmaceutical sciences |
| Volume | 77 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1988 |
ASJC Scopus subject areas
- Pharmaceutical Science
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