TY - JOUR
T1 - Solubility and partitioning IX
T2 - Solubility of hydantoins in water
AU - Pinal, Rodolfo
AU - Yalkowsky, Samuel H.
PY - 1988/6
Y1 - 1988/6
N2 - An expression for estimating the aqueous solubility of weak electrolytes under different conditions of temperature and pH has been proposed in a previous publication. The expression, based on the additivity of free energy, separates solubility into three independent contributions. In the present work, the equation is tested with a different set of 18 solutes within the range of temperature of 20 to 50 °C and of pH of 1 to 10. The results show that the theoretical relationship between aqueous solubility and the three independent contributions used in the equation is in excellent agreement with the experimental data.
AB - An expression for estimating the aqueous solubility of weak electrolytes under different conditions of temperature and pH has been proposed in a previous publication. The expression, based on the additivity of free energy, separates solubility into three independent contributions. In the present work, the equation is tested with a different set of 18 solutes within the range of temperature of 20 to 50 °C and of pH of 1 to 10. The results show that the theoretical relationship between aqueous solubility and the three independent contributions used in the equation is in excellent agreement with the experimental data.
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U2 - 10.1002/jps.2600770611
DO - 10.1002/jps.2600770611
M3 - Article
C2 - 3171932
AN - SCOPUS:0024230964
SN - 0022-3549
VL - 77
SP - 518
EP - 522
JO - Journal of pharmaceutical sciences
JF - Journal of pharmaceutical sciences
IS - 6
ER -