Socio-demographic and trauma-related predictors of PTSD within 8 weeks of a motor vehicle collision in the AURORA study

Ronald C. Kessler; Kerry J. Ressler; Stacey L. House; Francesca L. Beaudoin; Xinming An; Jennifer S. Stevens; Donglin Zeng; Thomas C. Neylan; Sarah D. Linnstaedt; Laura T. Germine; Paul I. Musey; Phyllis L. Hendry; Sophia Sheikh; Alan B. Storrow; Christopher W. Jones; Brittany E. Punches; Elizabeth M. Datner; Kamran Mohiuddin; Nina T. Gentile; Meghan E. McGrath; Sanne J. van Rooij; Lauren A. Hudak; John P. Haran; David A. Peak; Robert M. Domeier; Claire Pearson; Leon D. Sanchez; Niels K. Rathlev; William F. Peacock; Steven E. Bruce; Mark W. Miller; Jutta Joormann; Deanna M. Barch; Diego A. Pizzagalli; John F. Sheridan; Jordan W. Smoller; Thaddeus W.W. Pace; Steven E. Harte; James M. Elliott; Nathaniel G. Harnett; Lauren A.M. Lebois; Irving Hwang; Nancy A. Sampson; Karestan C. Koenen; Samuel A. McLean

doi:10.1038/s41380-020-00911-3

Socio-demographic and trauma-related predictors of PTSD within 8 weeks of a motor vehicle collision in the AURORA study

Ronald C. Kessler, Kerry J. Ressler, Stacey L. House, Francesca L. Beaudoin, Xinming An, Jennifer S. Stevens, Donglin Zeng, Thomas C. Neylan, Sarah D. Linnstaedt, Laura T. Germine, Paul I. Musey, Phyllis L. Hendry, Sophia Sheikh, Alan B. Storrow, Christopher W. Jones, Brittany E. Punches, Elizabeth M. Datner, Kamran Mohiuddin, Nina T. Gentile, Meghan E. McGrathSanne J. van Rooij, Lauren A. Hudak, John P. Haran, David A. Peak, Robert M. Domeier, Claire Pearson, Leon D. Sanchez, Niels K. Rathlev, William F. Peacock, Steven E. Bruce, Mark W. Miller, Jutta Joormann, Deanna M. Barch, Diego A. Pizzagalli, John F. Sheridan, Jordan W. Smoller, Thaddeus W.W. Pace, Steven E. Harte, James M. Elliott, Nathaniel G. Harnett, Lauren A.M. Lebois, Irving Hwang, Nancy A. Sampson, Karestan C. Koenen, Samuel A. McLean

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

This is the initial report of results from the AURORA multisite longitudinal study of adverse post-traumatic neuropsychiatric sequelae (APNS) among participants seeking emergency department (ED) treatment in the aftermath of a traumatic life experience. We focus on n = 666 participants presenting to EDs following a motor vehicle collision (MVC) and examine associations of participant socio-demographic and participant-reported MVC characteristics with 8-week posttraumatic stress disorder (PTSD) adjusting for pre-MVC PTSD and mediated by peritraumatic symptoms and 2-week acute stress disorder (ASD). Peritraumatic Symptoms, ASD, and PTSD were assessed with self-report scales. Eight-week PTSD prevalence was relatively high (42.0%) and positively associated with participant sex (female), low socioeconomic status (education and income), and several self-report indicators of MVC severity. Most of these associations were entirely mediated by peritraumatic symptoms and, to a lesser degree, ASD, suggesting that the first 2 weeks after trauma may be a uniquely important time period for intervening to prevent and reduce risk of PTSD. This observation, coupled with substantial variation in the relative strength of mediating pathways across predictors, raises the possibility of diverse and potentially complex underlying biological and psychological processes that remain to be elucidated with more in-depth analyses of the rich and evolving AURORA data.

Original language	English (US)
Pages (from-to)	3108-3121
Number of pages	14
Journal	Molecular Psychiatry
Volume	26
Issue number	7
DOIs	https://doi.org/10.1038/s41380-020-00911-3
State	Published - Jul 2021
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

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10.1038/s41380-020-00911-3

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Kessler, R. C., Ressler, K. J., House, S. L., Beaudoin, F. L., An, X., Stevens, J. S., Zeng, D., Neylan, T. C., Linnstaedt, S. D., Germine, L. T., Musey, P. I., Hendry, P. L., Sheikh, S., Storrow, A. B., Jones, C. W., Punches, B. E., Datner, E. M., Mohiuddin, K., Gentile, N. T., ... McLean, S. A. (2021). Socio-demographic and trauma-related predictors of PTSD within 8 weeks of a motor vehicle collision in the AURORA study. Molecular Psychiatry, 26(7), 3108-3121. https://doi.org/10.1038/s41380-020-00911-3

Kessler, RC, Ressler, KJ, House, SL, Beaudoin, FL, An, X, Stevens, JS, Zeng, D, Neylan, TC, Linnstaedt, SD, Germine, LT, Musey, PI, Hendry, PL, Sheikh, S, Storrow, AB, Jones, CW, Punches, BE, Datner, EM, Mohiuddin, K, Gentile, NT, McGrath, ME, van Rooij, SJ, Hudak, LA, Haran, JP, Peak, DA, Domeier, RM, Pearson, C, Sanchez, LD, Rathlev, NK, Peacock, WF, Bruce, SE, Miller, MW, Joormann, J, Barch, DM, Pizzagalli, DA, Sheridan, JF, Smoller, JW, Pace, TWW, Harte, SE, Elliott, JM, Harnett, NG, Lebois, LAM, Hwang, I, Sampson, NA, Koenen, KC & McLean, SA 2021, 'Socio-demographic and trauma-related predictors of PTSD within 8 weeks of a motor vehicle collision in the AURORA study', Molecular Psychiatry, vol. 26, no. 7, pp. 3108-3121. https://doi.org/10.1038/s41380-020-00911-3

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title = "Socio-demographic and trauma-related predictors of PTSD within 8 weeks of a motor vehicle collision in the AURORA study",

abstract = "This is the initial report of results from the AURORA multisite longitudinal study of adverse post-traumatic neuropsychiatric sequelae (APNS) among participants seeking emergency department (ED) treatment in the aftermath of a traumatic life experience. We focus on n = 666 participants presenting to EDs following a motor vehicle collision (MVC) and examine associations of participant socio-demographic and participant-reported MVC characteristics with 8-week posttraumatic stress disorder (PTSD) adjusting for pre-MVC PTSD and mediated by peritraumatic symptoms and 2-week acute stress disorder (ASD). Peritraumatic Symptoms, ASD, and PTSD were assessed with self-report scales. Eight-week PTSD prevalence was relatively high (42.0%) and positively associated with participant sex (female), low socioeconomic status (education and income), and several self-report indicators of MVC severity. Most of these associations were entirely mediated by peritraumatic symptoms and, to a lesser degree, ASD, suggesting that the first 2 weeks after trauma may be a uniquely important time period for intervening to prevent and reduce risk of PTSD. This observation, coupled with substantial variation in the relative strength of mediating pathways across predictors, raises the possibility of diverse and potentially complex underlying biological and psychological processes that remain to be elucidated with more in-depth analyses of the rich and evolving AURORA data.",

author = "Kessler, {Ronald C.} and Ressler, {Kerry J.} and House, {Stacey L.} and Beaudoin, {Francesca L.} and Xinming An and Stevens, {Jennifer S.} and Donglin Zeng and Neylan, {Thomas C.} and Linnstaedt, {Sarah D.} and Germine, {Laura T.} and Musey, {Paul I.} and Hendry, {Phyllis L.} and Sophia Sheikh and Storrow, {Alan B.} and Jones, {Christopher W.} and Punches, {Brittany E.} and Datner, {Elizabeth M.} and Kamran Mohiuddin and Gentile, {Nina T.} and McGrath, {Meghan E.} and {van Rooij}, {Sanne J.} and Hudak, {Lauren A.} and Haran, {John P.} and Peak, {David A.} and Domeier, {Robert M.} and Claire Pearson and Sanchez, {Leon D.} and Rathlev, {Niels K.} and Peacock, {William F.} and Bruce, {Steven E.} and Miller, {Mark W.} and Jutta Joormann and Barch, {Deanna M.} and Pizzagalli, {Diego A.} and Sheridan, {John F.} and Smoller, {Jordan W.} and Pace, {Thaddeus W.W.} and Harte, {Steven E.} and Elliott, {James M.} and Harnett, {Nathaniel G.} and Lebois, {Lauren A.M.} and Irving Hwang and Sampson, {Nancy A.} and Koenen, {Karestan C.} and McLean, {Samuel A.}",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s), under exclusive licence to Springer Nature Limited.",

year = "2021",

month = jul,

doi = "10.1038/s41380-020-00911-3",

language = "English (US)",

volume = "26",

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T1 - Socio-demographic and trauma-related predictors of PTSD within 8 weeks of a motor vehicle collision in the AURORA study

AU - Kessler, Ronald C.

AU - Ressler, Kerry J.

AU - House, Stacey L.

AU - Beaudoin, Francesca L.

AU - An, Xinming

AU - Stevens, Jennifer S.

AU - Zeng, Donglin

AU - Neylan, Thomas C.

AU - Linnstaedt, Sarah D.

AU - Germine, Laura T.

AU - Musey, Paul I.

AU - Hendry, Phyllis L.

AU - Sheikh, Sophia

AU - Storrow, Alan B.

AU - Jones, Christopher W.

AU - Punches, Brittany E.

AU - Datner, Elizabeth M.

AU - Mohiuddin, Kamran

AU - Gentile, Nina T.

AU - McGrath, Meghan E.

AU - van Rooij, Sanne J.

AU - Hudak, Lauren A.

AU - Haran, John P.

AU - Peak, David A.

AU - Domeier, Robert M.

AU - Pearson, Claire

AU - Sanchez, Leon D.

AU - Rathlev, Niels K.

AU - Peacock, William F.

AU - Bruce, Steven E.

AU - Miller, Mark W.

AU - Joormann, Jutta

AU - Barch, Deanna M.

AU - Pizzagalli, Diego A.

AU - Sheridan, John F.

AU - Smoller, Jordan W.

AU - Pace, Thaddeus W.W.

AU - Harte, Steven E.

AU - Elliott, James M.

AU - Harnett, Nathaniel G.

AU - Lebois, Lauren A.M.

AU - Hwang, Irving

AU - Sampson, Nancy A.

AU - Koenen, Karestan C.

AU - McLean, Samuel A.

PY - 2021/7

Y1 - 2021/7

N2 - This is the initial report of results from the AURORA multisite longitudinal study of adverse post-traumatic neuropsychiatric sequelae (APNS) among participants seeking emergency department (ED) treatment in the aftermath of a traumatic life experience. We focus on n = 666 participants presenting to EDs following a motor vehicle collision (MVC) and examine associations of participant socio-demographic and participant-reported MVC characteristics with 8-week posttraumatic stress disorder (PTSD) adjusting for pre-MVC PTSD and mediated by peritraumatic symptoms and 2-week acute stress disorder (ASD). Peritraumatic Symptoms, ASD, and PTSD were assessed with self-report scales. Eight-week PTSD prevalence was relatively high (42.0%) and positively associated with participant sex (female), low socioeconomic status (education and income), and several self-report indicators of MVC severity. Most of these associations were entirely mediated by peritraumatic symptoms and, to a lesser degree, ASD, suggesting that the first 2 weeks after trauma may be a uniquely important time period for intervening to prevent and reduce risk of PTSD. This observation, coupled with substantial variation in the relative strength of mediating pathways across predictors, raises the possibility of diverse and potentially complex underlying biological and psychological processes that remain to be elucidated with more in-depth analyses of the rich and evolving AURORA data.

AB - This is the initial report of results from the AURORA multisite longitudinal study of adverse post-traumatic neuropsychiatric sequelae (APNS) among participants seeking emergency department (ED) treatment in the aftermath of a traumatic life experience. We focus on n = 666 participants presenting to EDs following a motor vehicle collision (MVC) and examine associations of participant socio-demographic and participant-reported MVC characteristics with 8-week posttraumatic stress disorder (PTSD) adjusting for pre-MVC PTSD and mediated by peritraumatic symptoms and 2-week acute stress disorder (ASD). Peritraumatic Symptoms, ASD, and PTSD were assessed with self-report scales. Eight-week PTSD prevalence was relatively high (42.0%) and positively associated with participant sex (female), low socioeconomic status (education and income), and several self-report indicators of MVC severity. Most of these associations were entirely mediated by peritraumatic symptoms and, to a lesser degree, ASD, suggesting that the first 2 weeks after trauma may be a uniquely important time period for intervening to prevent and reduce risk of PTSD. This observation, coupled with substantial variation in the relative strength of mediating pathways across predictors, raises the possibility of diverse and potentially complex underlying biological and psychological processes that remain to be elucidated with more in-depth analyses of the rich and evolving AURORA data.

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ER -

Socio-demographic and trauma-related predictors of PTSD within 8 weeks of a motor vehicle collision in the AURORA study

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