Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death

Jin H. Song; Hyun Jin Kang; Libia A. Luevano; Vijay Gokhale; Kui Wu; Ritu Pandey; Hsiao-Hui Chow; Laurence H. Hurley; Andrew S. Kraft

doi:10.1016/j.chembiol.2019.04.009

Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death

Jin H. Song, Hyun Jin Kang, Libia A. Luevano, Vijay Gokhale, Kui Wu, Ritu Pandey, Hsiao-Hui Chow, Laurence H. Hurley, Andrew S. Kraft

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Small-molecule targeting of the cooperative folding process in the hTERT G-quadruplex promoter element produces telomerase-independent events, which impair mitochondrial processes resulting in apoptotic cell death and inhibition of prostate cancer cell growth.

Original language	English (US)
Pages (from-to)	1110-1121.e4
Journal	Cell Chemical Biology
Volume	26
Issue number	8
DOIs	https://doi.org/10.1016/j.chembiol.2019.04.009
State	Published - Aug 15 2019

Keywords

G-quadruplex
NRF2
ROS
docetaxel resistance
hTERT
oxidative stress
prostate cancer
telomerase

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1016/j.chembiol.2019.04.009

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@article{b8e198fe69fb42938afa1919e5107dcd,

title = "Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death",

abstract = "Small-molecule targeting of the cooperative folding process in the hTERT G-quadruplex promoter element produces telomerase-independent events, which impair mitochondrial processes resulting in apoptotic cell death and inhibition of prostate cancer cell growth.",

keywords = "G-quadruplex, NRF2, ROS, docetaxel resistance, hTERT, oxidative stress, prostate cancer, telomerase",

author = "Song, {Jin H.} and Kang, {Hyun Jin} and Luevano, {Libia A.} and Vijay Gokhale and Kui Wu and Ritu Pandey and Hsiao-Hui Chow and Hurley, {Laurence H.} and Kraft, {Andrew S.}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = aug,

day = "15",

doi = "10.1016/j.chembiol.2019.04.009",

language = "English (US)",

volume = "26",

pages = "1110--1121.e4",

journal = "Cell Chemical Biology",

issn = "2451-9456",

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TY - JOUR

T1 - Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death

AU - Song, Jin H.

AU - Kang, Hyun Jin

AU - Luevano, Libia A.

AU - Gokhale, Vijay

AU - Wu, Kui

AU - Pandey, Ritu

AU - Chow, Hsiao-Hui

AU - Hurley, Laurence H.

AU - Kraft, Andrew S.

PY - 2019/8/15

Y1 - 2019/8/15

N2 - Small-molecule targeting of the cooperative folding process in the hTERT G-quadruplex promoter element produces telomerase-independent events, which impair mitochondrial processes resulting in apoptotic cell death and inhibition of prostate cancer cell growth.

AB - Small-molecule targeting of the cooperative folding process in the hTERT G-quadruplex promoter element produces telomerase-independent events, which impair mitochondrial processes resulting in apoptotic cell death and inhibition of prostate cancer cell growth.

KW - G-quadruplex

KW - NRF2

KW - ROS

KW - docetaxel resistance

KW - hTERT

KW - oxidative stress

KW - prostate cancer

KW - telomerase

UR - http://www.scopus.com/inward/record.url?scp=85070227729&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070227729&partnerID=8YFLogxK

U2 - 10.1016/j.chembiol.2019.04.009

DO - 10.1016/j.chembiol.2019.04.009

M3 - Article

C2 - 31155510

AN - SCOPUS:85070227729

SN - 2451-9456

VL - 26

SP - 1110-1121.e4

JO - Cell Chemical Biology

JF - Cell Chemical Biology

IS - 8

ER -

Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death

Abstract

Keywords

ASJC Scopus subject areas

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