TY - JOUR
T1 - Small form factor, flexible, dual-modality handheld probe for smartphone-based, point-of-care oral and oropharyngeal cancer screening
AU - Uthoff, Ross D.
AU - Song, Bofan
AU - Sunny, Sumsum
AU - Patrick, Sanjana
AU - Suresh, Amritha
AU - Kolur, Trupti
AU - Gurushanth, Keerthi
AU - Wooten, Kimberly
AU - Gupta, Vishal
AU - Platek, Mary E.
AU - Singh, Anurag K.
AU - Wilder-Smith, Petra
AU - Kuriakose, Moni Abraham
AU - Birur, Praveen
AU - Liang, Rongguang
N1 - Funding Information:
We are grateful for our funding sources. This research was supported by the National Institute of Biomedical Imaging and Bioengineering of the U.S. National Institutes of Health (NIH) under Award No. UH2EB022623 and NIH Award No. 1S10OD018061-01A1. Uthoff received funding from the National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering, Graduate Training in Biomedical Imaging and Spectroscopy Grant No. T32EB000809. We would like to thank Pier Morgan and the Center for Gamma-Ray Imaging (CGRI) for assistance with the rapid prototype printer, Ken Almonte for guidance on the LED driver design, and David Coombs for PCB assembly assistance.
Publisher Copyright:
© The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Oral cancer is a growing health issue in low- and middle-income countries due to betel quid, tobacco, and alcohol use and in younger populations of middle- and high-income communities due to the prevalence of human papillomavirus. The described point-of-care, smartphone-based intraoral probe enables autofluorescence imaging and polarized white light imaging in a compact geometry through the use of a USB-connected camera module. The small size and flexible imaging head improves on previous intraoral probe designs and allows imaging the cheek pockets, tonsils, and base of tongue, the areas of greatest risk for both causes of oral cancer. Cloud-based remote specialist and convolutional neural network clinical diagnosis allow for both remote community and home use. The device is characterized and preliminary field-testing data are shared.
AB - Oral cancer is a growing health issue in low- and middle-income countries due to betel quid, tobacco, and alcohol use and in younger populations of middle- and high-income communities due to the prevalence of human papillomavirus. The described point-of-care, smartphone-based intraoral probe enables autofluorescence imaging and polarized white light imaging in a compact geometry through the use of a USB-connected camera module. The small size and flexible imaging head improves on previous intraoral probe designs and allows imaging the cheek pockets, tonsils, and base of tongue, the areas of greatest risk for both causes of oral cancer. Cloud-based remote specialist and convolutional neural network clinical diagnosis allow for both remote community and home use. The device is characterized and preliminary field-testing data are shared.
KW - autofluorescence imaging
KW - biomedical imaging
KW - mobile health
KW - oral cancer screening
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U2 - 10.1117/1.JBO.24.10.106003
DO - 10.1117/1.JBO.24.10.106003
M3 - Article
C2 - 31642247
AN - SCOPUS:85073761922
SN - 1083-3668
VL - 24
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
IS - 10
M1 - 106003
ER -