Small but mighty: inulin promotes small intestinal bacterial fructose feeding

Hallie R. Wachsmuth; Frank A. Duca

doi:10.1038/s42255-025-01374-y

Small but mighty: inulin promotes small intestinal bacterial fructose feeding

Hallie R. Wachsmuth
, Frank A. Duca

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Although the gut microbiome contributes to the development of metabolic disease, beneficially altering the gut microbiome via increased fibre intake improves metabolic outcomes in rodents and humans. A new study by Jung et al. describes a novel mechanism by which the prebiotic fibre, inulin, can prevent and reverse hepatic steatosis via adaptations in the small intestinal microbiome.

Original language	English (US)
Pages (from-to)	1720-1722
Number of pages	3
Journal	Nature Metabolism
Volume	7
Issue number	9
DOIs	https://doi.org/10.1038/s42255-025-01374-y
State	Published - Sep 2025
Externally published	Yes

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Physiology (medical)
Cell Biology

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10.1038/s42255-025-01374-y

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title = "Small but mighty: inulin promotes small intestinal bacterial fructose feeding",

abstract = "Although the gut microbiome contributes to the development of metabolic disease, beneficially altering the gut microbiome via increased fibre intake improves metabolic outcomes in rodents and humans. A new study by Jung et al. describes a novel mechanism by which the prebiotic fibre, inulin, can prevent and reverse hepatic steatosis via adaptations in the small intestinal microbiome.",

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AU - Duca, Frank A.

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Y1 - 2025/9

N2 - Although the gut microbiome contributes to the development of metabolic disease, beneficially altering the gut microbiome via increased fibre intake improves metabolic outcomes in rodents and humans. A new study by Jung et al. describes a novel mechanism by which the prebiotic fibre, inulin, can prevent and reverse hepatic steatosis via adaptations in the small intestinal microbiome.

AB - Although the gut microbiome contributes to the development of metabolic disease, beneficially altering the gut microbiome via increased fibre intake improves metabolic outcomes in rodents and humans. A new study by Jung et al. describes a novel mechanism by which the prebiotic fibre, inulin, can prevent and reverse hepatic steatosis via adaptations in the small intestinal microbiome.

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UR - https://www.scopus.com/pages/publications/105016398206#tab=citedBy

U2 - 10.1038/s42255-025-01374-y

DO - 10.1038/s42255-025-01374-y

M3 - Comment/debate

C2 - 40954285

AN - SCOPUS:105016398206

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JO - Nature Metabolism

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Small but mighty: inulin promotes small intestinal bacterial fructose feeding

Abstract

ASJC Scopus subject areas

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