Slow conformational motions that favor sub-picosecond motions important for catalysis

J. R.Exequiel T. Pineda; Dimitri Antoniou; Steven D. Schwartz

doi:10.1021/jp1071296

Slow conformational motions that favor sub-picosecond motions important for catalysis

J. R.Exequiel T. Pineda, Dimitri Antoniou, Steven D. Schwartz

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31 Scopus citations

Abstract

It has been accepted for many years that functionally important motions are crucial to binding properties of ligands in such molecules as hemoglobin and myoglobin. In enzymatic reactions, theory and now experiment are beginning to confirm the importance of motions on a fast (ps) time scale in the chemical step of the catalytic process. What is missing is a clear physical picture of how slow conformational fluctuations are related to the fast motions that have been identified as crucial. This paper presents a theoretical analysis of this issue for human heart lactate dehydrogenase. We will examine how slow conformational motions bring the system to conformations that are distinguished as catalytically competent because they favor specific fast motions.

Original language	English (US)
Pages (from-to)	15985-15990
Number of pages	6
Journal	Journal of Physical Chemistry B
Volume	114
Issue number	48
DOIs	https://doi.org/10.1021/jp1071296
State	Published - Dec 9 2010
Externally published	Yes

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Surfaces, Coatings and Films
Materials Chemistry

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Slow conformational motions that favor sub-picosecond motions important for catalysis

Abstract

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