TY - JOUR
T1 - Sleep Duration and Diabetes Risk
T2 - Population Trends and Potential Mechanisms
AU - Grandner, Michael A.
AU - Seixas, Azizi
AU - Shetty, Safal
AU - Shenoy, Sundeep
N1 - Funding Information:
This work was supported by K23HL110216.
Publisher Copyright:
© 2016, Springer Science+Business Media New York.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Sleep is important for regulating many physiologic functions that relate to metabolism. Because of this, there is substantial evidence to suggest that sleep habits and sleep disorders are related to diabetes risk. In specific, insufficient sleep duration and/or sleep restriction in the laboratory, poor sleep quality, and sleep disorders such as insomnia and sleep apnea have all been associated with diabetes risk. This research spans epidemiologic and laboratory studies. Both physiologic mechanisms such as insulin resistance, decreased leptin, and increased ghrelin and inflammation and behavioral mechanisms such as increased food intake, impaired decision-making, and increased likelihood of other behavioral risk factors such as smoking, sedentary behavior, and alcohol use predispose to both diabetes and obesity, which itself is an important diabetes risk factor. This review describes the evidence linking sleep and diabetes risk at the population and laboratory levels.
AB - Sleep is important for regulating many physiologic functions that relate to metabolism. Because of this, there is substantial evidence to suggest that sleep habits and sleep disorders are related to diabetes risk. In specific, insufficient sleep duration and/or sleep restriction in the laboratory, poor sleep quality, and sleep disorders such as insomnia and sleep apnea have all been associated with diabetes risk. This research spans epidemiologic and laboratory studies. Both physiologic mechanisms such as insulin resistance, decreased leptin, and increased ghrelin and inflammation and behavioral mechanisms such as increased food intake, impaired decision-making, and increased likelihood of other behavioral risk factors such as smoking, sedentary behavior, and alcohol use predispose to both diabetes and obesity, which itself is an important diabetes risk factor. This review describes the evidence linking sleep and diabetes risk at the population and laboratory levels.
KW - Circadian
KW - Diabetes
KW - Insomnia
KW - Obesity
KW - Sleep
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U2 - 10.1007/s11892-016-0805-8
DO - 10.1007/s11892-016-0805-8
M3 - Review article
C2 - 27664039
AN - SCOPUS:84988531520
SN - 1534-4827
VL - 16
JO - Current diabetes reports
JF - Current diabetes reports
IS - 11
M1 - 106
ER -