Sleep duration and 24-hour ambulatory blood pressure in adults not on antihypertensive medications

Rachel Shulman, Debbie L. Cohen, Michael A. Grandner, Thorarinn Gislason, Allan I. Pack, Samuel T. Kuna, Raymond R. Townsend, Jordana B. Cohen

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Short sleep duration has been widely linked to increased cardiovascular morbidity and mortality. We performed a post hoc analysis of 24-hour ambulatory blood pressure monitoring (ABPM) in the Lifestyle Modification in Blood Pressure Lowering Study (LIMBS) and Penn Icelandic Sleep Apnea (PISA) Study. The 24-hour mean systolic blood pressure (BP) was 12.7 mm Hg higher in LIMBS (P < 0.001; n = 66) and 4.7 mm Hg higher in PISA (P = 0.005; n = 153) among participants with shorter sleep duration (less than 7 hours) compared to those with longer sleep duration (at least 7 hours). In multivariable adjusted models, shorter sleep duration was strongly associated with higher systolic BP on 24-hour ABPM, independent of nocturnal BP and in-office BP. There was no effect modification by obstructive sleep apnea. Adults with shorter sleep duration may benefit from screening with 24-hour ABPM to promote earlier detection of hypertension and potentially mitigate their increased risk for future cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)1712-1720
Number of pages9
JournalJournal of Clinical Hypertension
Issue number12
StatePublished - Dec 2018


  • ambulatory
  • blood pressure monitoring
  • circadian rhythm
  • hypertension
  • obstructive sleep apnea
  • sleep deprivation
  • sleep disorders

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine


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