Sleep disturbance and depression as barriers to adherence

Kenneth D. Phillips, Linda Moneyham, Carolyn Murdaugh, Mary R. Boyd, Abbas Tavakoli, Kirby Jackson, Medha Vyavaharkar

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


This study examined the relationships among subjective sleep disturbance, depressive symptoms, and adherence to medications among HIV-infected women. HPV-infected women (N = 173) were recruited through community AIDS service organizations throughout South Carolina. Participants completed the Pittsburgh Sleep Quality Index (PSQI), the Centers for Epidemiological Studies Depression Scale (CES-D), and a modified version of the Adults AIDS Clinical Trials Group Adherence Baseline Questionnaire. Women who reported greater sleep disturbance also reported a higher level of depressive symptoms and reported poor adherence to their medication regimen. Depression helped to explain the relationship between sleep quality and adherence. Results indicate that assessment and management of sleep disturbance and depressive symptoms in women with HIV disease is important to promote medication adherence.

Original languageEnglish (US)
Pages (from-to)273-293
Number of pages21
JournalClinical nursing research
Issue number3
StatePublished - Aug 2005


  • Depressive symptoms
  • HIV disease
  • Medication adherence
  • Sleep quality
  • Women

ASJC Scopus subject areas

  • Nursing(all)


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