Sleep disorders in adult sickle cell patients

Sunil Sharma, Jimmy T. Efird, Charles Knupp, Renuka Kadali, Darla Liles, Kristin Shiue, Peter Boettger, Stuart F. Quan

    Research output: Contribution to journalArticlepeer-review

    45 Scopus citations


    Study Objectives: While sleep apnea has been studied in children with sickle cell disease (SCD), little is known about sleep disorders in adult sickle cell patients. The objective of this study was to evaluate sleep disordered breathing and its polysomnographic characteristics in adult patients with sickle cell disease. Methods: The analysis cohort included 32 consecutive adult SCD patients who underwent a comprehensive sleep evaluation and overnight polysomnography in an accredited sleep center after reporting symptoms suggesting disordered sleep or an Epworth Sleepiness Scale score ≥ 10. Epworth score, sleep parameters, comorbid conditions, and narcotic use were reviewed and compared in patients with and without sleep disordered breathing. SCD complication rates in the two groups also were compared. Results: In adult SCD patients who underwent overnight polysomnography, we report a high prevalence (44%) of sleep disordered breathing. Disease severity was mild to moderate (mean apnea-hypopnea index = 17/h (95% CI: 10-24/h). Concomitant sleep disorders, including insomnia complaints (57%) and delayed sleep-phase syndrome (57%), also were common in this population. In this limited cohort, we did not fi nd increased SCD complications associated with sleep disordered breathing in adult patients with sickle cell disease. Conclusions: A high burden of sleep disordered breathing and other sleep-related complaints were identifi ed in the adult sickle cell population. Our results provide important information on this unique population.

    Original languageEnglish (US)
    Pages (from-to)219-223
    Number of pages5
    JournalJournal of Clinical Sleep Medicine
    Issue number3
    StatePublished - 2015


    • Anemia
    • Obstructive sleep apnea
    • Sickle cell
    • Sleep

    ASJC Scopus subject areas

    • General Medicine


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