Sleep Disordered Breathing in Hypertrophic Cardiomyopathy

Salma I. Patel, Fadi E. Shamoun, Heidi Esser, Sairam Parthasarathy, Michael J. Ackerman, Jeffrey B. Geske, Steve R. Ommen, William T. Love, Virend K. Somers, Anwar A. Chahal, Johan M. Bos, Stephen S. Cha, Steven J. Lester

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Introduction: There is a paucity of scientific knowledge regarding the presence and nature of sleep disordered breathing (SDB) amongst patients with hypertrophic cardiomyopathy (HCM). SDB may contribute to morbidity and mortality in patients with HCM. The goal of this study was to characterize SDB among HCM patients and evaluate treatment patterns of, and adherence to, positive airway pressure (PAP) therapies. An additional aim was to characterize if PAP therapy was associated with mortality in patients with HCM. Methods: Retrospective review of consecutive adults with idiopathic HCM undergoing polysomnography (PSG) at the Mayo Clinic over a 10 year period. Type of PAP therapy and PAP adherence were obtained if PAP therapy was prescribed. Results: Ninety-four patients with HCM underwent PSG (age 56.3 ± 12.4 years; 62 males, [66%]). Median follow-up was 6 years. Most patients (n = 75, 80%) had obstructive sleep apnea (OSA), followed by a combination of obstructive and central sleep apnea (n = 6; 6%), and central sleep apnea (n = 1; 1%). Twenty-four percent (n = 18) of patients with OSA had treatment emergent central sleep apnea. The rest (n = 12, 13%) had normal PSG studies. Continuous PAP (n = 60) was the most commonly prescribed PAP modality followed by adaptive servo-ventilation (ASV; n = 10). For those patients with known adherence (n = 43), adherence was greater than 4 h a night for greater than 70% of the days for a majority of patients (n = 36; 83%). Mortality was not associated with SDB, PAP treatment or PAP adherence over the 10 year period. Conclusions: SDB is highly prevalent in patients with HCM. Continuous PAP therapy was the most common PAP therapy and PAP adherence was high. There was no association between SDB and mortality in this limited data set of patients with HCM.

Original languageEnglish (US)
Pages (from-to)3-9
Number of pages7
JournalSleep and Vigilance
Issue number1
StatePublished - Jun 1 2020


  • Central sleep apnea
  • Hypertrophic cardiomyopathy
  • Obstructive sleep apnea
  • Sleep apnea
  • Treatment emergent central sleep apnea

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health


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