Sirtuin inhibitor sirtinol is an intracellular iron chelator

R. Gautam, E. A. Akam, A. V. Astashkin, J. J. Loughrey, E. Tomat

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda.

Original languageEnglish (US)
Pages (from-to)5104-5107
Number of pages4
JournalChemical Communications
Volume51
Issue number24
DOIs
StatePublished - 2015
Externally publishedYes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • General Chemistry
  • Ceramics and Composites
  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Catalysis

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