Sirtuin inhibitor sirtinol is an intracellular iron chelator

R. Gautam; E. A. Akam; A. V. Astashkin; J. J. Loughrey; E. Tomat

doi:10.1039/c5cc00829h

Sirtuin inhibitor sirtinol is an intracellular iron chelator

R. Gautam, E. A. Akam, A. V. Astashkin, J. J. Loughrey, E. Tomat

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda.

Original language	English (US)
Pages (from-to)	5104-5107
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	24
DOIs	https://doi.org/10.1039/c5cc00829h
State	Published - 2015
Externally published	Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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10.1039/c5cc00829h

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abstract = "Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda.",

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AU - Loughrey, J. J.

AU - Tomat, E.

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2015

Y1 - 2015

N2 - Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda.

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Sirtuin inhibitor sirtinol is an intracellular iron chelator

Abstract

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CCDC 1036424: Experimental Crystal Structure Determination

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Sirtuin inhibitor sirtinol is an intracellular iron chelator

Abstract

ASJC Scopus subject areas

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Datasets

CCDC 1036424: Experimental Crystal Structure Determination

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