siRNAs and DNA methylation: seedy epigenetics

Rebecca A. Mosher; Charles W. Melnyk

doi:10.1016/j.tplants.2010.01.002

siRNAs and DNA methylation: seedy epigenetics

Rebecca A. Mosher, Charles W. Melnyk

Research output: Contribution to journal › Review article › peer-review

104 Scopus citations

Abstract

To understand how DNA sequence is translated to phenotype we must understand the epigenetic features that regulate gene expression. Recent research illuminates the complex interactions between DNA methylation, small RNAs, silencing of transposable elements, and genomic imprinting in the Arabidopsis (Arabidopsis thaliana) seed. These studies suggest that transposable elements reactivated in specific cells of the gametophyte and seed might enhance silencing of transposable elements in the germline and embryo. By sacrificing genomic integrity these cells might make an epigenetic rather than genetic contribution to the progeny. This research could have implications for interspecies hybridization, the evolution of genomic imprinting, and epigenetic communication from plant to progeny.

Original language	English (US)
Pages (from-to)	204-210
Number of pages	7
Journal	Trends in Plant Science
Volume	15
Issue number	4
DOIs	https://doi.org/10.1016/j.tplants.2010.01.002
State	Published - Apr 2010
Externally published	Yes

ASJC Scopus subject areas

Plant Science

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10.1016/j.tplants.2010.01.002

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@article{a3098211518b486fac3fd4f1bad67f45,

title = "siRNAs and DNA methylation: seedy epigenetics",

abstract = "To understand how DNA sequence is translated to phenotype we must understand the epigenetic features that regulate gene expression. Recent research illuminates the complex interactions between DNA methylation, small RNAs, silencing of transposable elements, and genomic imprinting in the Arabidopsis (Arabidopsis thaliana) seed. These studies suggest that transposable elements reactivated in specific cells of the gametophyte and seed might enhance silencing of transposable elements in the germline and embryo. By sacrificing genomic integrity these cells might make an epigenetic rather than genetic contribution to the progeny. This research could have implications for interspecies hybridization, the evolution of genomic imprinting, and epigenetic communication from plant to progeny.",

author = "Mosher, {Rebecca A.} and Melnyk, {Charles W.}",

note = "Funding Information: The authors wish to thank David Baulcombe for his mentorship and support, and Donna Bond for comments on the manuscript. C.W.M. is funded by Commonwealth and NSERC scholarships.",

year = "2010",

month = apr,

doi = "10.1016/j.tplants.2010.01.002",

language = "English (US)",

volume = "15",

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journal = "Trends in Plant Science",

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TY - JOUR

T1 - siRNAs and DNA methylation

T2 - seedy epigenetics

AU - Mosher, Rebecca A.

AU - Melnyk, Charles W.

N1 - Funding Information: The authors wish to thank David Baulcombe for his mentorship and support, and Donna Bond for comments on the manuscript. C.W.M. is funded by Commonwealth and NSERC scholarships.

PY - 2010/4

Y1 - 2010/4

N2 - To understand how DNA sequence is translated to phenotype we must understand the epigenetic features that regulate gene expression. Recent research illuminates the complex interactions between DNA methylation, small RNAs, silencing of transposable elements, and genomic imprinting in the Arabidopsis (Arabidopsis thaliana) seed. These studies suggest that transposable elements reactivated in specific cells of the gametophyte and seed might enhance silencing of transposable elements in the germline and embryo. By sacrificing genomic integrity these cells might make an epigenetic rather than genetic contribution to the progeny. This research could have implications for interspecies hybridization, the evolution of genomic imprinting, and epigenetic communication from plant to progeny.

AB - To understand how DNA sequence is translated to phenotype we must understand the epigenetic features that regulate gene expression. Recent research illuminates the complex interactions between DNA methylation, small RNAs, silencing of transposable elements, and genomic imprinting in the Arabidopsis (Arabidopsis thaliana) seed. These studies suggest that transposable elements reactivated in specific cells of the gametophyte and seed might enhance silencing of transposable elements in the germline and embryo. By sacrificing genomic integrity these cells might make an epigenetic rather than genetic contribution to the progeny. This research could have implications for interspecies hybridization, the evolution of genomic imprinting, and epigenetic communication from plant to progeny.

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DO - 10.1016/j.tplants.2010.01.002

M3 - Review article

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SP - 204

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JO - Trends in Plant Science

JF - Trends in Plant Science

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ER -

siRNAs and DNA methylation: seedy epigenetics

Abstract

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