TY - JOUR
T1 - Single-Pill vs Free-Equivalent Combination Therapies for Hypertension
T2 - A Meta-Analysis of Health Care Costs and Adherence
AU - Sherrill, Beth
AU - Halpern, Michael
AU - Khan, Shahnaz
AU - Zhang, Jie
AU - Panjabi, Sumeet
PY - 2011/12
Y1 - 2011/12
N2 - This meta-analysis compares health care resource use costs, adherence, and persistence between groups of patients taking antihypertensives as single-pill combinations (SPCs) vs free-equivalent components (FEC) based on a structured review of published studies. The search yielded 12 retrospective database studies included in analyses. The mean difference in combined total annual all-cause and hypertension-related health care costs was $1357 (95% confidence interval [CI], $778-$1935) lower in favor of SPC than FEC groups. Adherence, measured as the mean difference in medication possession ratio, was estimated to be 8% higher for patients naive to prior antihypertensives and 14% higher for nonnaive SPC patients compared with corresponding FEC patients. Persistence in the SPC groups was twice as likely as the FEC groups (pooled risk ratio, 2.1; 95% CI, 1.1-4.1). Improved adherence and persistence may have contributed to the lower costs in the SPC groups via improved clinical outcomes.
AB - This meta-analysis compares health care resource use costs, adherence, and persistence between groups of patients taking antihypertensives as single-pill combinations (SPCs) vs free-equivalent components (FEC) based on a structured review of published studies. The search yielded 12 retrospective database studies included in analyses. The mean difference in combined total annual all-cause and hypertension-related health care costs was $1357 (95% confidence interval [CI], $778-$1935) lower in favor of SPC than FEC groups. Adherence, measured as the mean difference in medication possession ratio, was estimated to be 8% higher for patients naive to prior antihypertensives and 14% higher for nonnaive SPC patients compared with corresponding FEC patients. Persistence in the SPC groups was twice as likely as the FEC groups (pooled risk ratio, 2.1; 95% CI, 1.1-4.1). Improved adherence and persistence may have contributed to the lower costs in the SPC groups via improved clinical outcomes.
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U2 - 10.1111/j.1751-7176.2011.00550.x
DO - 10.1111/j.1751-7176.2011.00550.x
M3 - Article
C2 - 22142349
AN - SCOPUS:83055176357
SN - 1524-6175
VL - 13
SP - 898
EP - 909
JO - Journal of Clinical Hypertension
JF - Journal of Clinical Hypertension
IS - 12
ER -