Single Cell Nanobiosensors for Dynamic Gene Expression Profiling in Native Tissue Microenvironments

Shue Wang; Reza Riahi; Na Li; Donna D. Zhang; Pak Kin Wong

doi:10.1002/adma.201502814

Single Cell Nanobiosensors for Dynamic Gene Expression Profiling in Native Tissue Microenvironments

Shue Wang, Reza Riahi, Na Li, Donna D. Zhang, Pak Kin Wong

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

A gold nanorod-locked nucleic acid nanobiosensor for dynamic single-cell gene expression analysis in living cells and tissues is developed. The nanoparticle facilitates endocytic delivery and dynamic monitoring of the gene expression in human umbilical cord endothelial cells, mouse skin tissues, mouse retina tissues, and mouse cornea tissues at the single-cell level.

Original language	English (US)
Pages (from-to)	6034-6038
Number of pages	5
Journal	Advanced Materials
Volume	27
Issue number	39
DOIs	https://doi.org/10.1002/adma.201502814
State	Published - Oct 1 2015

Keywords

biosensors
locked nucleic acids
nanoparticles
single cells
tissue microenvironments

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201502814

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title = "Single Cell Nanobiosensors for Dynamic Gene Expression Profiling in Native Tissue Microenvironments",

abstract = "A gold nanorod-locked nucleic acid nanobiosensor for dynamic single-cell gene expression analysis in living cells and tissues is developed. The nanoparticle facilitates endocytic delivery and dynamic monitoring of the gene expression in human umbilical cord endothelial cells, mouse skin tissues, mouse retina tissues, and mouse cornea tissues at the single-cell level.",

keywords = "biosensors, locked nucleic acids, nanoparticles, single cells, tissue microenvironments",

author = "Shue Wang and Reza Riahi and Na Li and Zhang, {Donna D.} and Wong, {Pak Kin}",

note = "Publisher Copyright: {\textcopyright} 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.",

year = "2015",

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T1 - Single Cell Nanobiosensors for Dynamic Gene Expression Profiling in Native Tissue Microenvironments

AU - Wang, Shue

AU - Riahi, Reza

AU - Li, Na

AU - Zhang, Donna D.

AU - Wong, Pak Kin

PY - 2015/10/1

Y1 - 2015/10/1

N2 - A gold nanorod-locked nucleic acid nanobiosensor for dynamic single-cell gene expression analysis in living cells and tissues is developed. The nanoparticle facilitates endocytic delivery and dynamic monitoring of the gene expression in human umbilical cord endothelial cells, mouse skin tissues, mouse retina tissues, and mouse cornea tissues at the single-cell level.

AB - A gold nanorod-locked nucleic acid nanobiosensor for dynamic single-cell gene expression analysis in living cells and tissues is developed. The nanoparticle facilitates endocytic delivery and dynamic monitoring of the gene expression in human umbilical cord endothelial cells, mouse skin tissues, mouse retina tissues, and mouse cornea tissues at the single-cell level.

KW - biosensors

KW - locked nucleic acids

KW - nanoparticles

KW - single cells

KW - tissue microenvironments

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JF - Advanced Materials

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ER -

Single Cell Nanobiosensors for Dynamic Gene Expression Profiling in Native Tissue Microenvironments

Abstract

Keywords

ASJC Scopus subject areas

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