Simultaneous T1 and B1+ mapping using reference region variable flip angle imaging

Kyunghyun Sung, Manojkumar Saranathan, Bruce L. Daniel, Brian A. Hargreaves

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Purpose To present a new method that can simultaneously and efficiently measure T1 and B1+ maps using reference region variable flip angle (RR-VFA) imaging. Methods Assuming T1 relaxation time in a reference region such as fat is well characterized, and the reference region sufficiently covers smoothly varying B1+ field inhomogeneity, B1+ maps can be measured from VFA images, conventionally used for T1 measurements. Fat-only images from two-point Dixon acquisitions were used to compute B1+ maps, and the B1+ maps were compared with ones using the double-angle method (DAM) in 22 breast MRI patients at 3T. Additionally, high spatial resolution VFA images were acquired to show T1 measurements with and without the RR-VFA B1+ correction in six patients. Results RR-VFA is able to generate reliable B1+ maps, similar to those using the conventional DAM. This simultaneous T 1 and B1+ mapping can also be used to reduce T1 estimation errors, where T1 maps have more uniform fibroglandular tissue T1 and better depiction of heterogeneous T 1 of breast masses. Conclusion A new method that can measure both T1 and B1+ maps based on Dixon VFA images is described, offering improved T1 quantification with no scan time penalty.

Original languageEnglish (US)
Pages (from-to)954-961
Number of pages8
JournalMagnetic Resonance in Medicine
Issue number4
StatePublished - Oct 2013
Externally publishedYes


  • T1 mapping
  • breast imaging
  • high-field MRI
  • quantitative DCE-MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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