@inproceedings{9a916e907f2142cda21d1acdee02ec9c,
title = "Simultaneous dual modality optical and MR imaging of mouse dorsal skin-fold window chamber",
abstract = "Optical imaging and MRI have both been used extensively to study tumor microenvironment. The two imaging modalities are complementary and can be used to cross-validate one another for specific measurements. We have developed a modular platform that is capable of doing optical microscopy inside an MRI instrument. To do this, an optical relay system transfers the image to outside of the MR bore to a commercial grade CCD camera. This enables simultaneous optical and MR imaging of the same tissue and thus creates the ideal situation for comparative or complementary studies using both modalities. Initial experiments have been done using GFP labeled prostate cancer cells implanted in mouse dorsal skin fold window chamber. Vascular hemodynamics and vascular permeability were studied using our imaging system. Towards this goal, we developed a dual MR-Optical contrast agent by labeling BSA with both Gd-DTPA and Alexa Fluor. Overall system design and results of these preliminary vascular studies are presented.",
keywords = "Dual-Modality, Fluorescence, MRI, Optical Imaging, Simultaneous, Vascular Permeability, Window Chamber",
author = "Salek, {Mir Farrokh} and Pagel, {Mark D.} and Gmitro, {Arthur F.}",
year = "2011",
doi = "10.1117/12.876529",
language = "English (US)",
isbn = "9780819484390",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX",
note = "Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX ; Conference date: 22-01-2011 Through 25-01-2011",
}