Simultaneous confidence bounds for low-dose risk assessment with nonquantal data

Walter W. Piegorsch; R. Webster West; Wei Pan; Ralph L. Kodell

doi:10.1081/B1P-200040804

Simultaneous confidence bounds for low-dose risk assessment with nonquantal data

Walter W. Piegorsch, R. Webster West, Wei Pan, Ralph L. Kodell

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We study the use of simultaneous confidence bounds for making low-dose inferences in quantitative risk analysis. Confidence limits are constructed for outcomes measured on a continuous scale, assuming a simple linear model for the observed response. From the simultaneous confidence hounds, simultaneous lower limits an the benchmark dose associated with a particular risk are also constructed.

Original language	English (US)
Pages (from-to)	17-31
Number of pages	15
Journal	Journal of Biopharmaceutical Statistics
Volume	15
Issue number	1
DOIs	https://doi.org/10.1081/B1P-200040804
State	Published - 2005
Externally published	Yes

Keywords

BMDL
Benchmark dose (BMD)
Low-dose extrapolation
Noncentrality parameter
Nonquantal dose response
Safety assessment
Simultaneous confidence bands

ASJC Scopus subject areas

Statistics and Probability
Pharmacology
Pharmacology (medical)

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10.1081/B1P-200040804

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title = "Simultaneous confidence bounds for low-dose risk assessment with nonquantal data",

abstract = "We study the use of simultaneous confidence bounds for making low-dose inferences in quantitative risk analysis. Confidence limits are constructed for outcomes measured on a continuous scale, assuming a simple linear model for the observed response. From the simultaneous confidence hounds, simultaneous lower limits an the benchmark dose associated with a particular risk are also constructed.",

keywords = "BMDL, Benchmark dose (BMD), Low-dose extrapolation, Noncentrality parameter, Nonquantal dose response, Safety assessment, Simultaneous confidence bands",

author = "Piegorsch, {Walter W.} and West, {R. Webster} and Wei Pan and Kodell, {Ralph L.}",

note = "Funding Information: The authors thank Philip M. Dixon and two anonymous reviewers for helpful input during the preparation of the manuscript. This research was funded under grant #R01-CA76031 from the U.S. National Cancer Institute. Its contents are solely the responsibility of the authors and do not necessarily reflect the official views of the National Cancer Institute.",

year = "2005",

doi = "10.1081/B1P-200040804",

language = "English (US)",

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T1 - Simultaneous confidence bounds for low-dose risk assessment with nonquantal data

AU - Piegorsch, Walter W.

AU - West, R. Webster

AU - Pan, Wei

AU - Kodell, Ralph L.

N1 - Funding Information: The authors thank Philip M. Dixon and two anonymous reviewers for helpful input during the preparation of the manuscript. This research was funded under grant #R01-CA76031 from the U.S. National Cancer Institute. Its contents are solely the responsibility of the authors and do not necessarily reflect the official views of the National Cancer Institute.

PY - 2005

Y1 - 2005

N2 - We study the use of simultaneous confidence bounds for making low-dose inferences in quantitative risk analysis. Confidence limits are constructed for outcomes measured on a continuous scale, assuming a simple linear model for the observed response. From the simultaneous confidence hounds, simultaneous lower limits an the benchmark dose associated with a particular risk are also constructed.

AB - We study the use of simultaneous confidence bounds for making low-dose inferences in quantitative risk analysis. Confidence limits are constructed for outcomes measured on a continuous scale, assuming a simple linear model for the observed response. From the simultaneous confidence hounds, simultaneous lower limits an the benchmark dose associated with a particular risk are also constructed.

KW - BMDL

KW - Benchmark dose (BMD)

KW - Low-dose extrapolation

KW - Noncentrality parameter

KW - Nonquantal dose response

KW - Safety assessment

KW - Simultaneous confidence bands

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Simultaneous confidence bounds for low-dose risk assessment with nonquantal data

Abstract

Keywords

ASJC Scopus subject areas

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