TY - JOUR
T1 - Simulation of electrophoretic separations by the flux-corrected transport method
AU - Sounart, T. L.
AU - Baygents, J. C.
N1 - Funding Information:
This work was supported, in part, by the NSF/SRC Center for Environmentally-Benign Semiconductor Manufacturing at The University of Arizona.
PY - 2000/8/25
Y1 - 2000/8/25
N2 - Electrophoretic separations at typical experimental electric field strengths have been simulated by applying the flux-corrected transport (FCT) finite difference method to the transient, one-dimensional electrophoresis model. The performance of FCT on simulations of zone electrophoresis (ZE), isotachophoresis (ITP), and isoelectric focusing (IEF) has been evaluated. An FCT algorithm, with a three-point, central spatial discretization, yields numerical solutions without numerical oscillations or spurious peaks, which have plagued previously-published second-order solutions to benchmark ZE and ITP problems. Moreover, the FCT technique captures sharp zone boundaries and IEF peaks more accurately than previously-published, first-order upwind schemes. (C) 2000 Elsevier Science B.V.
AB - Electrophoretic separations at typical experimental electric field strengths have been simulated by applying the flux-corrected transport (FCT) finite difference method to the transient, one-dimensional electrophoresis model. The performance of FCT on simulations of zone electrophoresis (ZE), isotachophoresis (ITP), and isoelectric focusing (IEF) has been evaluated. An FCT algorithm, with a three-point, central spatial discretization, yields numerical solutions without numerical oscillations or spurious peaks, which have plagued previously-published second-order solutions to benchmark ZE and ITP problems. Moreover, the FCT technique captures sharp zone boundaries and IEF peaks more accurately than previously-published, first-order upwind schemes. (C) 2000 Elsevier Science B.V.
KW - Computer simulation
KW - Electric field strength
KW - Flux-corrected transport
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U2 - 10.1016/S0021-9673(00)00500-8
DO - 10.1016/S0021-9673(00)00500-8
M3 - Article
C2 - 11009036
AN - SCOPUS:0034714613
SN - 0021-9673
VL - 890
SP - 321
EP - 336
JO - Journal of Chromatography A
JF - Journal of Chromatography A
IS - 2
ER -